首页
最新动态 交流合作 科研项目 论文著作 精彩瞬间 招生招聘
  • The bone formation in vitro and mandibular defect repair using PLGA porous scaffolds
  • 来源:任天斌教授个人网站 2009-05-13
  • Highly porous scaffolds of poly(lactide-co-glycolide) (PLGA) were prepared by solution-casting/salt-leaching method. The in vitro degradation behavior of PLGA scaffold was investigated by measuring the change of normalized weight, water absorption, pH, and molecular weight during degradation period. Mesenchymal stem cells (MSCs) were seeded and cultured in three-dimensional PLGA scaffolds to fabricate in vitro tissue engineering bone, which was investigated by cell morphology, cell number and deposition of mineralized matrix. The proliferation of seeded MSCs and their differentiated function were demonstrated by experimental results. To compare the reconstructive functions of different groups, mandibular defect repair of rabbit was made with PLGA/MSCs tissue engineering bone, control PLGA scaffold, and blank group without scaffold. Histopathologic methods were used to estimate the reconstructive functions. The result suggests that it is feasible to regenerate bone tissue in vitro using PLGA foams with pore size ranging from 100-250 m as scaffolding for the transplantation of MSCs, and the PLGA/MSCs tissue engineering bone can greatly promote cell growth and have better healing functions for mandibular defect repair. The defect can be completely recuperated after 3 months with PLGA/MSCs tissue engineering bone, and the contrastive experiments show that the defects could not be repaired with blank PLGA scaffold. PLGA/MSCs tissue engineering bone has great potential as appropriate replacement for successful repair of bone defect.
  • [来源:中国聚合物网]
  • 了解更多请进入: 任天斌教授个人网站
相关新闻
  • · The effects of salt concentration on ion state and conductivity in comb cross-linked polymer electrolytes
  • · Synthesis and characterization of novel crosslinked polyurethane-acrylate electrolyte
  • · Preparation, characterization, and properties of poly(vinyl chloride)/organophilic-montmorillonite nanocomposites
  • · Microwave plasma surface modification of silicone elastomer with Allylamine for improvement of biocompatibility

关于我们  |  联系我们  

网站:中国聚合物网

polymer.cn Copyright ©2017