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  • Influences of the content of POA on the properties of poly(sebacic acid-octadecanic diacid) copolyanhydrides
  • 来源:邓联东副教授个人网站 2009-09-10
  • Poly(sebacic acid-octadecanoic diacid) copolyanhydrides (PSAOAs) were prepared by melt
    polycondensation of sebacic acid (SA) and octadecanoic diacid (OA). PSAOAs were characterized
    by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry
    (DSC) and wide angle X-ray diffraction (XRD). In vitro degradation experiments and
    SEM micrographs show that the degradation rate of PSAOAs decrease with increasing
    the content of POA in copolyanhydrides and the erosion process of PSAOAs is neither bulk
    nor perfect surface erosion but rather has elements of both in phosphate buffer at 37 C. In
    vitro release experiments and SEM micrographs indicate that the release rate of drug from
    the drug-loaded PSAOAs discs decreases with increasing the content of POA in copolyanhydrides
    and the release rate of the hydrophilic drug is greater than that of the hydrophobic
    one. The results of the investigation suggest that POA can improve the properties of PSA
    and promote the applications of PSA in biomedicine.

  • [来源:中国聚合物网]
  • 了解更多请进入: 邓联东副教授个人网站
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