- Biocompatible Injectable Magnetic Hydrogel Formed by Dynamic Coordination Network
- 来源：施李杨副教授个人网站
2019-11-24
- Magnetic hydrogel that can respond for magnetic stimulus is a promising biomaterial for tissue regeneration and cancer treatment. In this study, a novel magnetic hydrogel is formed by simply mixing bisphosphonate (BP) modified hyaluronic acid (i.e. HA-BP) polymeric solution and iron oxide (Fe3O4) nanoparticle dispersion, in which the hydrogel networks are crosslinked by BP groups and iron atoms on the surface of particle. The iron-BP coordination chemistry affords a dynamic network, characterized by self-healing, shear-thinning, and smoothly-injectable properties. Moreover, the HA-BP?Fe3O4 magnetic hydrogel demonstrates heat-generation characterization under an alternating magnetic field. The animal experiments confirm the biocompatibilities of HA-BP?Fe3O4 hydrogel which presents the hydrogels potential for tissue regeneration and anti-cancer treatment applications.
- [来源：中国聚合物网]