内容简介：
【简介】 Institute of Biotechnology and Drug Research (IBWF), Kaiserslautern, Germany
At the IBWF, microbiologists, biochemists and chemists are joining forces to develop new biologically active substances as well as enzymes. Based on 25 years’ experience in these fields of research, they are able to offer a wide range of services.
The IBWF is open for collaborative projects and joint ventures in the public sector as well as with industrial partners.
Research and development activities at the IBWF focus on the following topics:
Discovery and development of fungal metabolites for agricultural and pharmaceutical applications. Isolation, identification and in vitro culturing of Basidiomycetes, Ascomycetes, Deuteromycetes and Zygomycetes. Characterization of these fungi in solid state and submerged fermentations up to pilot plant sizes. Optimization of fermentations. Isolation and characterization of metabolites and enzymes from fermentations. Screening for new bioactive compounds of natural or synthetic origin. Development of test systems, including reporter gene assays e.g. in human cell lines and plant-pathogenic fungi. Tests for antibacterial, antifungal, phytotoxic, nematicidal, insecticidal and cytostatic activities using enzymatic and cellular test systems. Mode of action studies. Identification of cellular and molecular targets of new compounds. Production and characterization of new fungal enzymes e.g. for the pulp and paper industry, production and characterization. Biotransformations and bioremediation with fungi. Biosynthesis of fungal metabolites. The current projects are carried out with funding from major German companies, the State of Rheinland-Pfalz, the German Ministry of Science and Education (BMBF) and the European Union.
The scientific experience of the IBWF's senior scientists is documented in over 400 refereed scientific publications as well as numerous national and international patents. A class of new fungicides, the strobilurins, first described by Anke and Steglich in 1976 has been developed to very successful fungicides by the BASF Company (Stroby?, Brio?, Discus?, Juwel?). A new class of nematicides discovered in a joint project with the Bayer AG is on a good way towards commercial application. Other candidates are "in the pipeline".
