内容简介：
【简介】 At Yale MB&B, their emphasis is on biological molecules and how they function. They seek fundamental new insights into the ways in which living systems function and evolve at the molecular level. From the control of gene expression to signaling to the folding and handling of proteins and RNA, the department covers most of the key areas of modern biology. From its inception, MB&B has heavily focussed on molecular structure. With its strong tradition in biophysics, the department demonstrates a broad interest in all structural aspects of biology.
Since its founding in 1969 as the product of a merger between the biophysics program on the central campus and the biochemistry department at the Yale School of Medicine, the Department has taken a special interest in structure and function of biomolecules in a variety of biological systems. The rapidly emerging sequence of the human genome is a more or less inert store of information that needs to be brought to life by structural and functional analyses, which will be in ever-increasing demand.
Department members continue a tradition of discovering new biochemical principles that lie at the heart of both basic research and applications to human health. Indeed, the intensification of structural, functional and computational studies of biomolecules has been accelerated by discoveries made in the Department. Prominent examples include:
Structure of chaperonin, a protein-folding machine Structure of HIV reverse transcriptase bound to an approved AIDS drug Mechanisms of DNA recombination and transposition Discovery of snRNPs and their roles in splicing Principles of RNA folding derived from structures of ribozymes Regulation of G-protein coupled receptors in cell signaling Elucidation of protein folds within a membrane
These and other discoveries have thrust the Department into a unique position among all biological science departments in the country and the world. environment & resources
The Department benefits from its affiliation with several departments including Molecular, Cellular and Developmental Biology, Chemistry, Cell Biology, Genetics and other basic science departments in the School of Medicine. Students frequently undertake projects of particular medical relevance, often in conjunction with laboratories located at the School of Medicine. The importance of being part of both a university and a medical school cannot be understated. MB&B serves as an intellectual bridge between the medical, biological and chemical research communities on campus. MB&B brings problems with medical implications to the attention of basic researchers.
