Chait, Brian T. Mass Spectrometry and Gaseous Ion Chemistry
Darnell, James E. Molecular Cell Biology
Darst, Seth Molecular Biophysics
Gaasterland, Terry Computational Genomics
Kapoor, Tarun Chemistry and Cell Biology
Konarska, Magda Molecular Biology and Biochemistry
MacKinnon, Roderick Molecular Neurobiology and Biophysics
Muir, Tom Synthetic Protein Chemistry
O'Donnell, Michael DNA Replication
Roeder, Robert G. Biochemistry and Molecular Biology
Sakmar, Thomas P. Molecular Biology and Biochemistry
Stebbins, C. Erec Structural Microbiology
Tuschl, Thomas RNA Molecular Biology
Werner, Milton H. Molecular Biophysics
Topics of Current Investigation Include:
Mechanism of chromosomal DNA replication; Structure and mechanism of RNA polymerase and transcription initiation complexes; Mechanism of pre-mRNA splicing; Structures of proteins controlling mRNA targeting; mRNA stabilization and degradation; Viral genome replication and translation; Signal transduction by G-protein-coupled receptors; Mechanism of signal transduction and activation of transcription by STAT proteins; Development of state-of-the-art mass spectrometric tools for macromolecules; Photochemistry, origin and evolution of photosynthesis and vision; Bioinformatics and evolutionary genomics; Small molecule probes of cellular processes; Combinatorial protein chemistry; Structural biology and mechanism of ion channels; Structural biology of host/pathogen interactions.
