内容简介：
【简介】 The Department of Biochemistry was formed in 1920 with the establishment of the Whitley Chair of Biochemistry, now held by Professor Edwin Southern, FRS. After much expansion in recent decades, it is one of the largest Departments of Biochemistry in the western world with over 30 senior academic members of staff, more than 150 postdoctoral workers and over 160 graduate research students. Together with support staff (approx. 130 persons) and undergraduate students, they number about 850 people in all, and employ more than 10% of the total staff in the University's non-clinical Science Departments.
The Department is housed in seven buildings that make up the main department and its six units and sub-departments, namely the Genetics Unit, the Glycobiology Institute, the Laboratory of Molecular Biophysics, the Microbiology Unit, the MRC Biochemical and Clinical Magnetic Resonance Unit and the MRC Immunochemistry Unit.
Research is both diverse and interdisciplinary, and is currently broadly based into three main areas: Molecular Genetics, Molecular Cell Biochemistry and Structural Biology. The laboratories possess `state of the art' facilities for nuclear magnetic resonance, protein and DNA sequencing, protein crystallography, in vitro cell culture, molecular biology, proteomics, mass spectrometry and many others. These facilities are excellently supported by a modern research library, networked computers, a photographic unit and a variety of workshops.
The Department was one of only three Departments of Biochemistry in the country to receive a 5 (A) rating in the last Research Assessment Exercise. It was also awarded the highest possible rating in March 2000 by the Quality Assessment Agency for the standard of its teaching.
Research Groups:
Dr Margaret Adams Structure of pentose phosphate pathway enzymes Dr Andrew Almond The role of molecular dynamics in extracellular matrix organisation. Prof Judy Armitage Flagellar rotation and intracellular signalling pathways controlling bacterial chemotaxis Dr Ben Berks Bacterial protein transport and bacterial energy metabolism Dr Garry Brown Genetic defects of mitochondrial energy metabolism Prof Iain Campbell Structure and function of proteins in cell adhesion and signalling Dr Ronald Chalmers The mechanism of transposition and DNA repair in bacteria and higher eukaryotes Dr Ronald Chalmers Functional Genomics of Pathogenic Bacteria Dr Lynne Cox Replicative senescence: towards an understanding of cellular ageing Dr Tony Day Hyaluronan binding proteins in extracellular matrix and cell migration Dr Kristy Downing NMR Studies of Modular Proteins Implicated in Human Disease Dr David Dressler Molecular cell biology Prof Kurt Drickamer Molecular function of animal lectins in cellular recognition events Prof Raymond Dwek, Dr David Harvey, Dr Mark Wormald Structural and conformational analysis of oligosaccharides glycopeptides and glycoproteins Dr Jane Endicott Structural studies on the cyclin-dependent protein kinase family Prof Stuart Ferguson Structure function and biogenesis of bacterial respiratory proteins Dr Elspeth Garman X-ray Crystallography Data Collection Methods and Structural Studies on Neuraminidases Dr Penny Handford Molecular analysis of the Marfan Syndrome and related disorders Dr David Harris Regulation of the mitochondrial ATP synthase in cardiac and smooth muscle in normal and pathological states Prof Jonathan Hodgkin Developmental genetics, cellular morphogenesis and bacterial infection in the nematode C. elegans Prof Dame Louise Johnson Structural studies on regulatory proteins of the cell cycle and protein kinases Dr Nicholas Kent Chromatin structure and function in model eukaryotes. Dr Nick Lakin Detection, Signalling and Repair of DNA Damage. Dr Susan Lea Structural Studies on Host-Pathogen Interactions Dr Petros Ligoxygakis Monitoring the propagation of a microbial infection in vivo. Professor Louis Mahadevan Kinase cascades targeted to transcription factors and nucleosomal proteins involved in gene induction Dr Jim McDonnell Molecular structure and interactions in allergy and apoptosis Dr Jane Mellor Chromatin remodeling and gene regulation in simple eukaryotes Dr Sarah Newbury The role of mRNA stability in the control of Drosophila development Dr Martin Noble Structural studies on regulatory proteins Dr Catherine Pears The role of kinases in the choice of cell fate Dr Fran Platt & Dr Terry Butters Glycoprotein and Glycolipid Biosynthesis Dr Jennifer Potts Structural Studies of Fibronectin-Mediated Bacterial Invasion of Host Cells Prof Ken Reid The collectins - C-type lectins containing collagen-like regions - assessment of their roles in innate immunity Dr Pauline Rudd The role of glycosylation in the immune system and inflammation Prof Mark Sansom Ion channels and membrane proteins - simulations, modelling & bioinformatics Prof David Sherratt Recombination and Chromosome Segregation Dr Bob Sim Innate immunity and autoimmunity Prof Ed Southern Genome analysis Prof Peter Styles The application of magnetic resonance to the understanding of the biochemical basis of disease Dr Maureen Taylor The role of the mannose receptor in innate and adaptive immunity Dr Chris Tyler-Smith Molecular studies of mammalian chromosomes the Y chromosome and human evolution Prof Anthony Watts Resolving structural details of membrane peptides and proteins at high resolution Dr Matthew Whitby The mechanisms of genetic recombination and DNA repair in fission yeast Dr Alison Woollard Molecular mechanisms controlling cell fate determination in C. elegans Prof Michael Yudkin The establishment of differential gene expression and regulation of the general stress response in Bacillus subtilis Dr Nicole Zitzmann Hepatitis - Development of Antiviral Strategies
