| |
Mg2+/Ca2+ binding to DNA bases: a quantum chemical method and ABEEMrp/MM fluctuating charge model study
The interactions of Mg2+ and Ca2+ binding to adenine, cytosine, guanine, and thymine at various binding sites were studied by a high-level quantum chemical method and ABEEMrp/MM fluctuating charge model. The geometries and binding energies of M2+-bases complexes were determined at CCSD(T)/6-311++G(2d,2p)//MP2/6-311++G(2d,2p) level of theory, with the basis set&nb...
http://www.polymer.cn//ss/cyyu/publicationsshow_6723.html |
| |
2-Methyl-3-chloro-9-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine Hydrochloride: Crystal Structure and Interaction with DNA
The title compound, C9H8ClN2O2+Cl-,is a hydrochloric acid salt of 2-methyl-3-chloro-9- hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one, which is an important intermediate for the synthesis of biologically active heterocyclic compounds. The synthesized compound was characterized by 1H NMR and X-ray crystallography. The structure was solved in monoclinic, space group P21/n with a = 11.8295 (12), b = 6.2214...
http://www.polymer.cn//ss/sunbw/publicationsshow_6103.html |
| |
Synthesis, crystal structure and DNA binding properties of a new member of the [Mn3Zn2](13+) complex family
Two new 1-D coordination polymers [MII(3-Bzpy)2(N(CN)2)2](M = Cd (1), Cu (2), 3-Bzpy =3-benzoylpyridine) have been synthesized and structurally characterized by single-crystal X-ray diffraction and IR. Single-crystal X-ray diffraction reveals that the complexes 1 and 2 are isostructural and all crystallize in mono-clinic P21/c space group with cell dimensions: a =6.3889(16) A。, b = 7.6496(12) A。...
http://www.polymer.cn//ss/sunbw/publicationsshow_6100.html |
| |
Poly(2-aminoethyl methacrylate) with well-defined chain length for DNA vaccine delivery to dendritic cells
Poly(2-aminoethyl methacrylate) (PAEM) homopolymers with defined chain length and narrow molecular weight distribution were synthesized using atom transfer radical polymerization (ATRP), and a comprehensive study was conducted to evaluate the colloidal properties of PAEM/plasmid DNA polyplexes, the uptake and subcellular trafficking of polyplexes in antigen-presenting dend...
http://www.polymer.cn//ss/tangrupei/publicationsshow_5497.html |
| |
Journal of Materials Chemistry 2011: Dendrimer modified magnetic iron oxide nanoparticle/DNA/PEI ternary magnetoplexes: a novel strategy for magnetofection
As a powerful technology to enhance the efficiency of gene delivery, magnetofection has attracted considerable attention in the past decade. In this work, we introduced 6 generation of PAMAM dendrimer modified superparamagnetic nanoparticles (DMSPION-G6) to PEI/DNA polyplexes by a two-step process and enhanced the transfection efficiency of PEI with the help of a magnetic field. We prepared DMSPIO...
http://www.polymer.cn//ss/huangshiwen/publicationsshow_3464.html |
| |
Studies on Synthesis of Water-Soluble Polymer-supported Transition Metal Polypyridyl Complexes and their interaction with DNA
Five water-soluble polymer-supported transition metal polypyridyl complexes were synthesized from polyacrylic acid -co- N-vinyl pyrrolidone, 2-methyl-3-hydroxyl benzaldehyde, o-phenanthroline and metal acetate salts. Infrared spectra (IR), thermo-gravimetric and differential thermal analysis (TG-DTA), Inductance Coupling Plasma (ICP) and X-ray photoelectron spectroscopy (XPS) measurement technolog...
http://www.polymer.cn//ss/zhangfaai/publicationsshow_2256.html |
| |
多重响应性、力学强度可调的 Polypeptide-DNA 水凝胶
关键字：聚多肽-DNA 水凝胶，多重响应性，力学性质可调，生物相容性
超分子水凝胶由于其可解离和自愈合的性质，在组织工程和药物传输中有着很大的潜在应用而日益受到人们的重视。但是，传统的超分子水凝胶很难同时满足以下组织工程要求的条件：生理条件下快速原位生成、适当的力学强度、可设计的多重响应性、良好的生物相容性和生物降解性。近年来 polypeptide 由于其明确的二级结构和良好的生物降解性在自组装、生物材料等领域得到了广泛应用，与此同时，DNA 作为一种新型的超分子组装单元有着...
http://www.polymer.cn/research/sy_info16864 |
| |
DNA 自组装金纳米棒用于癌症的光热-化疗联合治疗
关键字：癌症，联合治疗，小牛胸腺 DNA，金纳米棒，光热效应
本课题中，我们构建了一种能够同时实现化疗和光热治疗的新型递药系统。该系统以具有近红外（near-infrared, NIR）光热效应的金纳米棒（Gold Nanorods，GNRs）为载体，采用层层自组装技术（layer-by-layer），将小牛胸腺DNA包覆到GNRs表面，构建GNRs-DNA@DOX体系。小牛胸腺 DNA 作为一类生物大分子，具有极好的生物相容性、低毒性、可降解性和较为稳定的双螺旋空间结构，是小分子抗癌药物递送的可选载体之一。
http://www.polymer.cn/research/sy_info16792 |
| |
Resolution limit for DNA barcodes in the Odijk regime
关键字：蠕虫状链，排除体积效应，空间受限，微纳米通道，DNA条形码技术
We develop an approximation for the probability of optically resolving two fluorescent labels on the backbone of a DNA molecule confined in a nanochannel in the Odijk regime as a function of the fluorescence wavelength, channel size, and the properties of the DNA (persistence length and effective width). The theoretical predictions agree well with equivalent data produced by Monte Carlo simulation...
http://www.polymer.cn/research/sy_info15088 |
| |
多重响应性、力学强度可调的 Polypeptide-DNA 水凝胶
关键字：聚多肽-DNA 水凝胶，多重响应性，力学性质可调，生物相容性
超分子水凝胶由于其可解离和自愈合的性质，在组织工程和药物传输中有着很大的潜在应用而日益受到人们的重视。但是，传统的超分子水凝胶很难同时满足以下组织工程要求的条件：生理条件下快速原位生成、适当的力学强度、可设计的多重响应性、良好的生物相容性和生物降解性。近年来 polypeptide 由于其明确的二级结构和良好的生物降解性在自组装、生物材料等领域得到了广泛应用，与此同时，DNA 作为一种新型的超分子组装单元有着...
http://www.polymer.cn/research/dis_info18397 |
| |