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Preparation of Reduction-triggered Degradable Microcapsules for Intracellular Delivery of anti-Cancer Drug and Gene
The reduction-triggered degradable poly(methacrylic acid-co-N,N-bis(acryloyl)cystamine)/polyethyleneimine (P(MAA-co-BAC)/PEI) microcapsules were prepared by distillationeprecipitation polymerization for delivery of anti-cancer drug and gene. N,N-bis(acryloyl)cystamine (BAC) as a crosslinker containing a disulfide bond can be triggered by reductive agents, such as glutathione (GSH) and dithiothreit...
http://www.polymer.cnt//ss/yangxinlin/publicationsshow_6539.html |
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Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions
Reduction and pH dual-sensitive reversibly core-crosslinked polypeptide micelles were developed from lipoic acid (LA) and cis-1,2-cyclohexanedicarboxylic acid (CCA) decorated poly(ethylene glycol)-b-poly(l-lysine) (PEG-P(LL-CCA/LA)) block copolymers for active loading and triggered intracellular release of doxorubicin (DOX). PEG-P(LL18-CCA4/LA14) and PEG-P(LL18-CCA8/LA10) (MnPEG = 5.0&nb...
http://www.polymer.cnt//ss/zhongzhiyuan/publicationsshow_4805.html |
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In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins
In situ forming reduction-sensitive degradable nanogels were designed and developed based on poly(ethylene glycol)-b-poly(2-(hydroxyethyl) methacrylate-co-acryloyl carbonate) (PEG-P(HEMA-co-AC)) block copolymers for efficient loading as well as triggered intracellular release of proteins. PEG-P(HEMA-co-AC) copolymers were prepared with controlled Mn of 9.1, 9.5, and 9.9 kg/mol and varying numbers ...
http://www.polymer.cnt//ss/zhongzhiyuan/publicationsshow_4803.html |
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Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding
The reduction-sensitive shedding of hydrophilic shells has recently emerged as a simple, effective and general approach to achieve markedly improved intracellular drug release from micelles. Here, the effects of disulfide content on reduction-sensitivity, triggered drug release and the anti-tumor activity of shell-sheddable micelles self-assembled from a mixture of reducible poly(ethylene glycol)&...
http://www.polymer.cnt//ss/zhongzhiyuan/publicationsshow_4792.html |
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Acid and reduction dually cleavable amphiphilic comb-like copolymer micelles for controlled drug delivery
http://pubs.rsc.org/en/content/articlelanding/2013/py/c3py00252g
Disulfide- and acetal-functionalized comb-like copolymers (SACP) with poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) side chains and a polymethacrylate backbone were synthesized and self-assembled for in vitro encapsulation and release of an anticancer drug, doxorubicin (DOX). Three step reactions inclu...
http://www.polymer.cnt//ss/zhaoyouliang/publicationsshow_4623.html |
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Fabrication of promising LiFePO4/C composite with a core-shell structure by a moderate in situ carbothermal reduction method
How to improve the power density of olivine LiFePO4 has recently become one of the most attractive topics of both scientific and industrial interests. Therefore, nanostructured electrodes have been widely investigated to satisfy such needs. However, the complicated and high-temperature sintering process is usually involved for preparing high-performance cathode materials based on high-quality crys...
http://www.polymer.cnt//ss/lutklb/publicationsshow_4270.html |
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Reduction-sensitive core-cross-linked mPEG–poly(ester-carbonate) micelles for glutathione-triggered intracellular drug release
A functionalized six-membered cyclic carbonate monomer containing a protected thiol group, 2-(2,4-
dinitrophenylthio)ethyl-5-methyl-2-oxo-1,3-dioxane-5-carboxylate (MTC), was prepared. Ring-
opening polymerization (ROP) of MTC and L-lactide (LA) initiated by monohydroxyl poly(ethylene
glycol) (mPEG) was successfully performed with controlled polymer molecular weight and molecular
weight distri...
http://www.polymer.cnt//ss/ciacxie/publicationsshow_3915.html |
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Ionic Iridium(III) Complexes with Bulky Side Groups for Use in Light Emitting Cells: Reduction of Concentration Quenching
Here, the photophysics and performance of single-layer light emitting cells (LECs) based on a series of ionic cyclometalated Ir(III) complexes of formulae [Ir(ppy)2( bpy)]+ PF6- and [Ir(ppy)2(phen)]+ PF6- where ppy, bpy, and phen are 2-phenylpyridine, substituted bipyridine and substituted phenanthroline ligands, respectively, are reported. Substitution at the N^N ligand has little effect on the e...
http://www.polymer.cnt//ss/zengxianshun/publicationsshow_3381.html |
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Controlled synthesis of single-crystal VOx·nH2O nanoribbons via a hydrothermal reduction method
VOx·nH2O (2.0x2.5) nanoribbons have been synthesized by direct hydrothermal processing of the aqueous solution of NH4VO3 and polyethylene glycol 400 (PEG-400) at pH 3.5–5.5. Techniques of XRD, SEM, TEM, HRTEM, ED, and XPS have been used to characterize the structure, morphology, and composition of the nanoribbons. The VOx·nH2O nanoribbons are up to 200 μm in length, 100...
http://www.polymer.cnt//ss/liuzhaoping/publicationsshow_2861.html |
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Templated synthesis of polyaniline nanotubes with Pd nanoparticles attached onto their inner walls and its catalytic activity on the reduction of p-nitroanilinum
In this paper, polyaniline (PANI) nanotubes with palladium nanoparticles (NPs) attached onto their inner walls were synthesized via a templating method which contains three steps. First, electrospun polystyrene (PS) nanofibers were coated with nearly monodispersed Pd NPs (d = 3.411 nm, σ = 0.687 nm, d is the average diameter of Pd NPs and σ is the standard deviation of their diameters) through i...
http://www.polymer.cnt//ss/wangce/publicationsshow_2705.html |
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