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[Acs Appl Mater Interfaces] Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers
作者:Haozheng Wang, Shi Qiang et al.
关键字:自适应性,抗氧化性表面
论文来源:期刊
具体来源:ACS Appl. Mater. Interfaces 2017, 9, 38313-38322
发表时间:2017年

Cells were continuously exposed to oxidative damage by overproduction

of reactive oxygen species (ROS) when they contacted implanted

biomaterials. The strategy to prevent cells from oxidative injures remains a

challenge. Inspired by the antioxidant defense system of cells, we constructed a

biocompatible and ROS-responsive architecture on the substrate of styrene-b-

(ethylene-co-butylene)-b-styrene elastomer (SEBS). The strategy was based on

fabrication of architectures through reactive electrospinning of mixture including

SEBS, acylated Pluronic F127, copolymer of poly(ethylene glycol) diacrylate and

1,2-ethanedithiol (PEGDA?EDT), and antioxidants (AA-2G) and ROS-triggered

release of AA-2G from microfibers to detoxify the excess ROS. We demonstrated

that the stable and hydrophilic architecture was constructed by phase separation of

SEBS/F127 components and cross-linking between polymer chains during

electrospinning; the ROS-responsive fibers controlled the release of AA-2G and

the interaction of AA-2G with ROS reduced the oxidative damage to cells. The

bioinspired architecture not only reduced mechanical and oxidative damage to cells but also maintained normal ROS level for physiological hemostasis. This work provides basic principles to design and develop antioxidative biomaterials for implantation in

vivo.