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Synthesis of an Amphiphilic Dendrimer-like Block Copolymer and its Application on Drug Delivery
writer:Wang S, Song X, Feng X*, Chen P*, Qian J, Xia R, Miao J
keywords:Amphiphilic Copolymer, Dendrimer, Living Anionic Polymerization
specific source:Chin. J. Chem. Phys.
Issue time:2014年
Dendrimer-like amphiphilic cop olymer is a kind of three-dimensional spherical structure
polymer. An amphiphilic dendrimer-like diblo ck cop olymer, PEEGE-G2-b-PEO(OH) 12,
constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H-NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH) 12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.