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Influences of the content of POA on the properties of poly(sebacic acid-octadecanic diacid) copolyanhydrides
作者:Yinglei Zhai, Shutao Guo, Anjie Dong, Fengmin Jin, Chaopeng Xie, Jinwei Zhang, Liandong Deng
关键字:Polyanhydrides,Poly(octadecanoic anhydride),Poly(sebacic acid-octadecanoic diacid),Biodegradable polymers,Poly(sebacic anhydride)
论文来源:期刊

Poly(sebacic acid-octadecanoic diacid) copolyanhydrides (PSAOAs) were prepared by melt
polycondensation of sebacic acid (SA) and octadecanoic diacid (OA). PSAOAs were characterized
by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry
(DSC) and wide angle X-ray diffraction (XRD). In vitro degradation experiments and
SEM micrographs show that the degradation rate of PSAOAs decrease with increasing
the content of POA in copolyanhydrides and the erosion process of PSAOAs is neither bulk
nor perfect surface erosion but rather has elements of both in phosphate buffer at 37 C. In
vitro release experiments and SEM micrographs indicate that the release rate of drug from
the drug-loaded PSAOAs discs decreases with increasing the content of POA in copolyanhydrides
and the release rate of the hydrophilic drug is greater than that of the hydrophobic
one. The results of the investigation suggest that POA can improve the properties of PSA
and promote the applications of PSA in biomedicine.