writer：Wei Tian*, Xiaodong Fan, Jie Kong*, Yuyang Liu, Tao Liu, Yi Huang
keywords：β-cyclodextrin,hyperbranched polymer,selective encapsulation
source：期刊
specific source：Polymer 51 (2010) 2556-2564
Issue time：2010年

Novel supramolecular system of amphiphilic hyperbranched polymer with hyperbranched poly(bcyclodextrin)
core was designed and synthesized to accomplish a so-called selective encapsulation,
where two types of guest molecules can be encapsulated into two types of molecular cavities from bcyclodextrin
(b-CD) and topography structure of hyperbranched polymer, respectively. The double
molecular recognition behaviors from b-CD and hyperbranched cavities drive one guest to go into the
former, the other guest to the latter. This selective encapsulation was further confirmed via the release
profiles and sequences of Levofloxacin lactate (LL) and Phenolphthalein (PP). LL presents a sustained
release period followed by an almost non-release stage, while PP releases on a quite slow rate at first,
subsequently on the linearly increasing rate. At the early stage, the release of LL dominates in comparison
with PP, and then the release rate of PP increases to play a determinate role in the release system. It can
be attributed to the existence of two guests in the different molecular cavities with the different
microenvironments. The observed selective encapsulation of supramolecular system is a new
phenomenon, which is helpful to extend the application of CD-based hyperbranched polymers in
supramolecular science and complex drug delivery system.