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[Polym. Chem.] A biomimicking and electrostatic self-assembly strategy for the preparation of glycopolymer decorated photoactive nanoparticles
作者:Kui Chen, Meimei Bao, Alexandra Mu?oz Bonilla, Weidong Zhang* and Gaojian Chen*
关键字:http://pubs.rsc.org/en/Content/ArticleLanding/2016/PY/C6PY00129G#!divAbstract
论文来源:期刊
具体来源:Polym. Chem., 2016,7, 2565-2572
发表时间:2016年
Novel and well-controlled copolymers, PDMA-co-PDMAEMA with bio-inspired dopamine-containing segments and electropositive PDMAEMA segments, PMAG-b-PMAA consisting of bio-targeted glucose-containing segments and electronegative PMAA segments, and a carboxyl-ending PMAG homopolymer, were synthesized and investigated by a combination of NMR, GPC, DLS and zeta potential measurements. After self-assembling the dopamine-containing polymer with Zn phthalocyanine (ZnPc) and decorating it with the sugar polymer PMAG-b-PMAA, the final nanoparticles presented better serum-stability and singlet oxygen quantum yields. More importantly, the in vitro and in vivo PDT experiments indicated that the pre-designed photoactive nanoparticles can well inhibit the growth of tumor cells.