writer：Weijiang Yu, Guohua Jiang*, Depeng Liu, Lei Li, Hua Chen, Yongkun Liu, Qin Huang, Zaizai Tong, Jumin
keywords：Transdermal, insulin, microneedles
source：期刊
specific source：Materials Science and Engineering, C, 2017, 73, 425-428.
Issue time：2017年

Abstract: The organic-inorganic bioceramic composite microneedles (MNs) were prepared from hydroxyapatite (Hap) and gelatin (Gel) via a template method. The resultant hydroxyapatite and gelatin composite MNs exhibited low cytotoxicity and excellent mechanical properties. After transdermal administration to the diabetic rats, the insulin could be released from bioceramic composite MNs. An obvious and effective hypoglycemic effect could be obtained compared with that of subcutaneous injection route. This work suggests that bioceramic composite MNs containing of insulin have a potential application in diabetes treatment via transdermal ingestion.