writer：10. Bin He*, Jing Zeng, Yu Nie, Li Ji, Rui Wang, Yao Wu, Li Li, Gang Wang, Zhongwei Gu*
keywords：biodegradable, supramolecular hydrogel, gelation
source：期刊
specific source：Macromol. Biosci. 2009, 9, 1169–1175
Issue time：2009年

A supramolecular injectable hydrogel was fabricated. The hydrogel was in situ gelated by the host-guest interaction between a-cyclodextrins (a-CDs) and methylated poly(ethylene glycol) grafted poly(a,b-malic acid) (mPEG-g-PMA). The hydrogel was characterized by 1NMR, XRD, DSC, TGA and SEM. The results showed that the polyrotaxanes of alpha-CDs/mPEG-g-PMA acted as physical crosslink sites in the hydrogel. Anti-tumor drug doxorubicin hydrochloride (DOX) was loaded in the hydrogel. The release and anti-tumor
effect were studied in vitro. The burst release of DOX was restrained obviously. The sustaining release time lasted more than 3 d and the cell viability decreased greatly. This hydrogel is a promising injectable hydrogel for minimally invasive therapeutic drug delivery.