writer：Lijie Ji, Kuilin Lai, Bin He*, Gang Wang, Liqing Song, Yao Wu, Zhongwei Gu*
keywords：Poly(L-lactide-co-Trimethylene Carbonate), Biocompatibility, Electrospun
source：期刊
specific source：Biomed. Mater., 2010, 5:045009 (7pp).
Issue time：2010年

The biomedical applications of poly(L-lactide) (PLLA) were limited by its high crystallinity. In this paper, the copolymerization of trimethylene carbonate (TMC) and L-lactide (LLA) was carried out to improve the flexibility of PLLA. The effects of the feeding dose, reaction temperature and polymerization time were investigated and the copolymers were characterized with ¹H NMR, FTIR, GPC, DSC, TGA and XRD. The copolymers were electrospun porous film to study their cell compatibility. The results showed that the composition of the copolymer was nearly the same as that in feeding dose and the molecular weight of copolymer decreased with increasing TMC content. The decreasing of the reaction temperature and polymerization time would increase the molecular weight, but the composition deviated away from the feeding dose. The NIH/3T3 mouse fibroblast cells were cultured on the electrospun films. The morphology and proliferation of the cell were studied. The reults  implied that the cell compatibility of ply(L-lactide-co-trimethylene carbonate) copolymer was much better than that of PLLA homopolymer.