writer：Jie Cui; Wei Jiang
keywords：ABCA tetrablock copolymer, vesicle, Monte Carlo simulation, selective solvent, self-assembly, hydrophobic layer, asymmetric membrane
source：期刊
specific source：Langmuir, 2011, 27, 10141-10147
Issue time：2011年

本文利用Monte Carlo模拟研究了ABCA四嵌段共聚物在对A块选择性的溶剂中形成的囊泡。模拟结果表明，块B和C的链长比和疏水性是决定囊泡疏水层结构的关键因素。如果B和C块疏水性相同，较长的C块倾向形成闭合的疏水层，而较短的B块定位在闭合疏水层外表面。但如果B和C之间的疏水性差异足够大，则会发生相反的情况。动力学研究显示，疏水层结构是通过聚合物链在囊泡膜内迁移形成的，这种迁移与链长比和疏水性差异无关。

Vesicles formed by ABCA tetrablock copolymers in solvents that are selective for block A are studied using the Monte Carlo simulation. Simulation results show that the chain length ratio and hydrophobicity of blocks B and C are key factors determining the hydrophobic layer structure of the vesicles. If the B and C blocks are of the same hydrophobicity, the longer block C tends to form the closed hydrophobic layer, whereas the shorter block B is located on the outer surface of the closed hydrophobic layer. However, if the hydrophobicity difference between blocks B and C is high enough, the reverse will occur. The kinetics of vesicle formation is also studied. Simulation results reveal that the hydrophobic layer structure is formed through the migration of the polymer chain within the vesicle membrane after the formation of the vesicle profile.

论文链接：https://doi.org/10.1021/la202377t