writer：Xiaobo Nie, Wei Jiang
keywords：量子点, 嵌段共聚物, 杂化胶束, 协同组装, 荧光探针, Janus结构
source：期刊
specific source：RSC Advances, 2014, 4(38), 19613-19621
Issue time：2014年

摘要：通过溶液相自组装方法，将单分散聚苯乙烯（PS）接枝的半导体量子点（QDs）高效封装到PS-b-PEO胶束的PS核中。研究表明，通过调节初始溶液中QDs和/或嵌段共聚物的浓度，可在热力学或动力学上调控共组装体的尺寸和QD负载数；改变QD尺寸、搅拌时间等实验参数还可获得多种QD/BCP杂化组装体形貌。该工作首次报道了一种新颖的Janus复合结构，由不含QDs的囊泡部分和富含QDs的球形部分组成；Janus复合体不稳定，倾向于转变为以球形QD负载胶束为主的形貌。QD/BCP杂化组装体具有良好水溶性、稳定性、低毒性和高发光性能，在生物领域尤其是荧光探针和标记方面具有应用潜力。

Abstract：The efficient encapsulation of monodisperse polystyrene (PS)-grafted semiconductor quantum dots (QDs) into the PS cores of PS-b-PEO micelles through a solution phase self-assembly approach is introduced. The size and the QD loading number of the coassemblies can be thermodynamically or kinetically tuned by varying the concentration of QDs and/or block copolymer (BCP) in the initial solution. Diverse morphologies of QD/BCP hybrid assemblies can be obtained by tuning experimental parameters such as the size of QDs and stirring time. A novel Janus complex comprising a vesicular part without QDs and a spherical part with lots of QDs was firstly reported in this work. The Janus complexes were unstable and tended to transform into predominantly spherical QD-loaded micelles. The QD/BCP hybrid assemblies present good water solubility, stability, lower toxicity and high luminous performance, indicating their potential applications in the biological field, especially as fluorescence probes and labels.

论文链接：https://doi.org/10.1039/c4ra02175d