writer：Ming Wu, Yutian Zhu, Wei Jiang
keywords：聚合物囊泡, 静电场, 可控释放, 两亲性嵌段共聚物, 形貌转变
source：期刊
specific source：ACS Macro Letters, 2016, 5(11), 1212-1216
Issue time：2016年

摘要：研究发现，由两亲性嵌段共聚物聚苯乙烯-b-聚丙烯酸（PS144-b-PAA22）在二氧六环/水混合溶剂中自组装形成的聚合物囊泡，可在外部静电场作用下发生变形、破裂并最终分裂为更小的囊泡。静电场强度越高，得到的囊泡越小。更重要的是，这种由静电场诱导的分裂现象可用于控制囊泡的释放行为。实验结果表明，封装在囊泡空腔内的尼罗红（NR）分子可通过控制静电场强度和释放时间实现精确释放。这些发现不仅丰富了外场诱导聚合物结构转变的知识，也为溶液中聚合物囊泡的可控释放提供了一种新的、非常便捷的方法。

Abstract：We found that the polymeric vesicles from the self-assembly of amphiphilic block copolymer polystyrene-block-poly(acrylic acid) (PS144-b-PAA22) in the dioxane/water mixture can be deformed, broken and finally divided into smaller ones via the external electrostatic field. The higher the electrostatic field intensity, the smaller the vesicles. More importantly, this fission phenomenon induced by electrostatic field can be used to control the release behavior of the vesicles. Our experimental results show that the Nile Red (NR) molecules encapsulated inside the cavity of vesicles can be accurately released by controlling the electrostatic field intensity and the release time. These findings not only enrich the knowledge for the external field induced transformation of polymer structures, but also provide a new and highly convenient approach for the controllable release of polymersomes in solution.

论文链接：https://doi.org/10.1021/acsmacrolett.6b00699