writer：Zhida Wang, Yuan Gan, Changfeng Yan, Ying Huang, Wei Jiang
keywords：自组装, 解组装, 可逆转变, 温度, ABC三嵌段共聚物
source：期刊
specific source：Polymer, 2016, 90, 276-281
Issue time：2016年

摘要：研究了仅通过改变温度诱导的PS720-P2VP200-PEO375多隔室胶束在水溶液中的自组装与解组装可逆转变。由纳米级小球在20°C下二次自组装形成的梭形胶束，在温度升高至40°C时会解组装为小的球形胶束；将体系冷却回20°C后，大尺寸胶束重新生成，但低温下再生的速度远慢于高温下的解组装速度。在中间区域30°C附近发现临界温度，此时胶束尺寸达到最大。临界温度随三嵌段共聚物分子量的变化而变化，并随亲水嵌段比例降低而向低温区移动。这种可逆转变被认为是球形胶束二次组装与溶剂-疏水嵌段相互作用参数共同作用的结果，在温度触发的药物递送和释放方面具有巨大应用潜力。

Abstract：Reversible transition of self-assembly and disassembly for PS720-P2VP200-PEO375 multicompartment micelles in aqueous solution induced solely by changing temperature has been investigated. The shuttle-like micelles, formed from a second self-assembly of nano-sized spheres at 20°C, will disassemble to small spherical micelles as the temperature increases to 40°C. Cooling the system back to 20°C regenerates the large-sized micelles, while the regeneration at low temperature is much slower than the disassembly at high temperature. A critical temperature is found at the intermediate regime of 30°C, at which the micelle reaches the maximum dimension. However, the critical temperature is observed to vary with the molecular weights of triblock copolymers and shifts to lower region with the decrease of the fraction of hydrophilic blocks. This reversible transition is considered as a result from the combination of the second-assembly of spherical micelles and the interaction parameter between the solvent and the hydrophobic block, and has great potential in application in drug delivery and release triggered by temperature.

论文链接：https://doi.org/10.1016/j.polymer.2016.03.036