writer：Yanqiu Du, Chunming Li, Jing Jin, Chao Li, Wei Jiang
keywords：聚异丁烯, 表面改性, 氨基酸聚合物刷, 抗污, 刀豆球蛋白A, 血液相容性
source：期刊
specific source：Colloids and Surfaces B: Biointerfaces, 2018, 161, 73-82
Issue time：2018年

摘要：采用等离子体预处理与紫外诱导接枝聚合相结合的方法，在聚异丁烯（PIB）表面制备了氨基酸基聚丙烯酰基-6-氨基己酸（PAACA）刷，以构建防污且功能化的材料。水接触角和血小板黏附测试表明，AACA表面改性显著提高了PIB的亲水性和血液相容性。将PAACA刷精确定位于PIB表面形成图案化PIB-g-PAACA结构，再活化PAACA上的羧基以固定功能蛋白刀豆球蛋白A（Con A），得到的Con A偶联微域可进一步捕获红细胞。该方法在商用PIB表面构建了基于氨基酸聚合物刷的平台，在药物递送和疾病诊断方面具有应用前景。

Abstract：Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA were activated to immobilize functional protein-Concanavalin A (Con A). The obtained Con A-coupled microdomains could further capture erythrocytes. This method developed a platform on commercial PIB surface via amino acid-based polymer brushes which had a promising application in drug delivery and disease diagnosis.

论文链接：https://doi.org/10.1016/j.colsurfb.2017.10.035