writer：Jianhua Lv, Bin Sun, Jing Jin, Wei Jiang
keywords：硅藻土, PAAm/硅藻土复合水凝胶, 多菌灵, 力学性能, 缓释
source：期刊
specific source：Materials Science and Engineering: C, 2019, 99, 315-321
Issue time：2019年

摘要：将硅藻土这一有前景的天然材料填充到聚丙烯酰胺（PAAm）中，制备了PAAm/硅藻土复合水凝胶。利用衰减全反射傅里叶变换红外光谱（ATR-FTIR）和扫描电子显微镜（SEM）表征了PAAm/硅藻土复合水凝胶的内部化学结构和硅藻土分散情况，并系统研究了不同硅藻土含量复合水凝胶的力学性能、吸水性和透明度。添加8 phr硅藻土后，PAAm/硅藻土复合水凝胶的拉伸强度和压缩强度分别提高2倍和13倍；复合水凝胶的吸水性和透明度随硅藻土含量增加而降低。硅藻土不仅是PAAm水凝胶本体的填料，还通过氢键与PAAm连接。以广谱苯并咪唑类杀菌剂多菌灵研究复合水凝胶的释放性能和动力学，发现PAAm水凝胶可降低多菌灵释放速率并延长药效，尤其是硅藻土复合水凝胶；多菌灵从硅藻土复合水凝胶释放一半所需时间延长近4天，释放机理为非正常传输。因此，硅藻土可提高PAAm水凝胶力学性能并延长负载多菌灵的药效；该复合水凝胶可应用于减少药物损失和浪费、延长生物医学材料中药物的作用时间。

Abstract：Diatomite as a promising natural material is filled into poly(acrylamide) (PAAm) to synthesize PAAm/diatomite composite hydrogel. The internal chemistry structure of PAAm/diatomite composite hydrogel and the diatomite dispersion are characterized via attenuated total reflection Fourier transform infrared (ATR-FTIR) and scanning electron microscopy (SEM). The mechanical property, water absorbency, and transparency of PAAm/diatomite composite hydrogels filled with different contents of diatomite are systematically investigated. The tensile and compressive strengths of PAAm/diatomite composite hydrogels are improved twice and 13-fold with 8 phr of diatomite. The water absorbency and transparency of PAAm/diatomite composite hydrogel decrease with the increase of diatomite content. The diatomite in PAAm hydrogels is not merely filling the bulk of PAAm hydrogel but is connecting with PAAm via hydrogen bonding. Carbendazim as a broad-spectrum benzimidazole fungicide is used to investigate the release property and kinetics of the composite hydrogels. The PAAm hydrogels can decrease the release rate of carbendazim and prolong the carbendazim efficacy, especially for the diatomite composite hydrogel. The time of half carbendazim release from the diatomite composite hydrogel is prolonged for almost 4 days, and the release mechanism is anomalous transport. Thus, diatomite can improve the mechanical property of PAAm hydrogel and extend the carbendazim efficacy loaded with PAAm hydrogel. Considering more widely applicable, the diatomite composite hydrogel can be applied to reduce the loss and waste of drugs and prolong the duration of drugs in biomedical materials.

论文链接：https://doi.org/10.1016/j.msec.2019.01.109