writer：Ming Wu, Yingying Wang, Nan Yan, Jing Jin, Yuanyuan Han, Wei Jiang
keywords：聚合物纳米囊泡, 超囊泡, 自组装, 多隔室封装, 软受限
source：期刊
specific source：Macromolecules, 2021, 54(4), 1905-1911
Issue time：2021年

摘要：本文开发了一种简便而通用的方法，利用水包1-丁醇乳液软受限体系，将均匀聚合物纳米囊泡自组装成双层超囊泡。封闭双层由聚合物纳米囊泡构成，形成分级超囊泡。有趣的是，通过简单混合两种不同尺寸的均匀纳米囊泡，可良好调控超囊泡双层结构从对称到不对称：较大纳米囊泡更倾向于分离到外层，较小纳米囊泡倾向于分离到内层，形成不对称分级超囊泡。通过分别向不同尺寸原始囊泡空腔装载不同货物，可将不同货物良好地选择性封装到不对称超囊泡的内层和外层多隔室中。这种可选择性多隔室封装为实现聚合物囊泡的多种功能提供了可能，此前尚未见报道。

Abstract：A facile yet universal approach to the self-assembly of uniform polymeric nanovesicles into bilayer supervesicles is developed using a water-in-1-butanol emulsion soft-confined system. The enclosed bilayer is constructed by polymeric nanovesicles, forming hierarchical supervesicles. Interestingly, the bilayer structure of supervesicles from symmetry to asymmetry is well tailored by simply mixing two different sizes of uniform nanovesicles. The larger nanovesicles are more likely to be segregated in the outer layer, while the smaller nanovesicles tend to be segregated into the inner layer, forming asymmetric hierarchical supervesicles. Different cargoes can thereby be well selectively encapsulated into the inner-layer and outer-layer multicompartment of the asymmetric supervesicles by loading different cargoes into the cavities of the original vesicles with different sizes separately. Such selectable multicompartmental encapsulation provides the possibility to realize the multiple functions of polymeric vesicles and has not been reported to date.

论文链接：https://doi.org/10.1021/acs.macromol.0c02400