writer：Xin Yu, Jinlan Li, Jianing Zhang, Jing Jin, Yanxiong Pan, Xiangling Ji, Wei Jiang
keywords：聚合物囊泡, 形貌转变, 紫外光, 路径依赖, 药物递送
source：期刊
specific source：Langmuir, 2024, 40(33), 17630-17637
Issue time：2024年

摘要：聚合物粒子的形貌转变通常是非平衡动力学过程。由于聚合物在药物递送和癌症治疗中的广泛应用，控制聚合物形貌转变日益吸引科学家关注且充满挑战。本文研究了由聚苯乙烯-b-聚4-乙烯基吡啶与4-羟基偶氮苯（PS-b-P4VP(Azo-OH)）组装的聚合物囊泡的紫外光触发形貌转变路径，以及紫外辐照PS-b-P4VP(Azo-OH)均相溶液的直接组装路径。在形貌转变过程中，良好组装的囊泡可转变为环形、圆柱形、棒状和球形胶束；在直接组装路径中可获得棒状和球形胶束。有趣的是，环形胶束只能通过紫外光触发形貌转变路径获得。对比两条路径揭示了PS-b-P4VP(Azo-OH)组装的路径依赖性，表明最终组装形貌由初始状态和动力学过程决定。通过调节紫外辐照强度、时间以及Azo-OH添加量，可方便调控紫外光触发形貌转变速度和组装体最终形貌。此外，光响应聚合物囊泡可作为药物载体，具有精确释放药物的潜力。

Abstract：Shape transformation of polymer particles is generally a nonequilibrium dynamics process. Controlling the shape transformation of polymers is increasingly attractive and challenging for scientists due to their extensive use in drug delivery and cancer therapy. Herein, we investigated the UV-triggered shape transformation pathway of polymeric vesicles assembled from polystyrene-block-poly(4-vinylpyridine) and 4-hydroxyazobenzene (PS-b-P4VP(Azo-OH)) and the direct assembly pathway of UV-irradiated PS-b-P4VP(Azo-OH) homogeneous solution. In the shape transformation process, well-assembled vesicles can be transformed into toroid, cylindrical, rod-like, and spherical micelles. In the direct assembly pathway, rod-like and spherical micelles can be obtained. Interestingly, the toroid micelles can be obtained only from the UV-triggered shape transformation pathway. Contrasting the two pathways reveals the pathway dependence of PS-b-P4VP(Azo-OH) assembly, suggesting that the final assembly morphology is determined by the initial state and dynamic process. The speed of UV-triggered shape transformation and the final morphology of assemblies can be tuned easily by adjusting the UV illuminance, time, and content of Azo-OH addition. Moreover, the light-responsive polymeric vesicles can be used as drug carriers and have the potential to release drugs precisely.

论文链接：https://doi.org/10.1021/acs.langmuir.4c01995