作者：Jiangping Xu, Yuanyuan Han, Jie Cui, Wei Jiang
关键字：金纳米粒子, 嵌段共聚物, 囊泡, 尺寸选择性, 自组装, 自洽场模拟
论文来源：期刊
具体来源：Langmuir, 2013, 29(33), 10383-10392
发表时间：2013年

结合实验与自洽场模拟，系统研究了两亲性嵌段共聚物囊泡壁可嵌入不同尺寸金纳米粒子（AuNPs）的程度。结果表明，AuNPs在囊泡壁或球形胶束中的位置强烈依赖尺寸，是否进入囊泡壁由AuNPs直径D0与囊泡壁厚度dw0之比决定：D0/dw0<0.3的十二硫醇包覆AuNPs可稳定分散在囊泡壁中；聚苯乙烯包覆AuNPs的判据为D0/dw0<0.5。能量分析显示AuNPs逸出囊泡壁并选择性分布于球形胶束是熵驱动过程。该研究为稀溶液中制备纳米粒子/嵌段共聚物杂化囊泡提供了重要指导。

A systematic study combining experiments and self-consistent field simulations revealed how far the polymeric vesicle wall can embed gold nanoparticles with different sizes. The location of AuNPs in vesicle walls or spherical micelles is heavily size dependent and is determined by the ratio of the AuNP diameter (D0) to the vesicle wall thickness (dw0). 1-Dodecanethiol-coated AuNPs with D0/dw0<0.3 stably disperse in vesicle walls, while polystyrene-coated AuNPs with D0/dw0<0.5 can be located in the vesicle wall. The results demonstrate that the escape of AuNPs from vesicle walls and their selective distribution in spherical micelles is an entropy-driven process, providing an important guideline for fabricating nanoparticle/block copolymer hybrid vesicles in dilute solution.

论文链接：https://doi.org/10.1021/la402132x