摘要：内外冠层组成不同的不对称囊泡因其在膜渗透性和蛋白质定位方面的独特功能，可应用于微反应器、药物递送和仿生等领域。本文开发了一种构建不对称囊泡的新方法，并首次展示了聚合物囊泡从对称膜到不对称膜的结构转变。实验结果和Monte Carlo模拟结果清楚表明，增强的冠状层间排斥和提高的疏水链迁移能力是实现这种转变的关键。此外，在加入HCl或NaOH改变冠状层间相互作用时，观察到相似的转变过程，表明该结构转变由物理相互作用而非化学环境主导。构建的不对称囊泡可在其外冠层选择性地修饰金纳米粒子。该研究为制备不对称囊泡提供了新方法，并为聚合物囊泡从对称到不对称膜结构转变的机理提供了见解。

Abstract：Asymmetric vesicles with different inner and outer corona compositions are applicable in microreactors, drug delivery, and biomimics because of their unique functions in membrane permeability and protein localization. In this study, we develop a novel approach to construct asymmetric vesicles and demonstrate the first structural transformation of polymeric vesicles from symmetric to asymmetric membranes. Experimental results and Monte Carlo simulation results clearly reveal that increased intercorona repulsion and enhanced hydrophobic chain mobility are essential to realize this transformation. Moreover, similar transformation processes are observed where either HCl or NaOH is added to change the intercorona interaction. This finding indicates that the observed structural transformation is dominated by physical interactions rather than chemical environment. The constructed asymmetric vesicles can be selectively decorated with gold nanoparticles on the outer corona. This study introduces a novel approach to prepare asymmetric vesicles and provides insights into the mechanism underlying the structural transformation of polymeric vesicles from symmetric to asymmetric membranes.

论文链接：https://doi.org/10.1039/c7sm00255f