作者：Ming Wu, Yingying Wang, Yuanyuan Han, Jie Cui, Wei Jiang
关键字：聚合物囊泡, 均匀尺寸, 尺寸可调, 共溶剂法, 嵌段共聚物, Monte Carlo模拟
论文来源：期刊
具体来源：Nanoscale, 2018, 10(31), 14860-14867
发表时间：2018年

摘要：囊泡的尺寸和尺寸均匀性决定其能否在广泛的生物和生物医学应用中充分发挥潜力。本文报道了一种简单而通用的共溶剂方法，可直接制备由两亲性嵌段共聚物聚4-乙烯基吡啶-b-聚苯乙烯（P4VP77-b-PS318）形成的尺寸可调（100-150 nm）均匀聚合物囊泡。只需向聚合物溶液中一次性加入足量选择性溶剂并静置过夜，即可轻松获得均匀聚合物囊泡。研究发现，均匀囊泡以固定尺寸形成，囊泡之间不再发生融合，DLS测得的囊泡PDI可低至0.03。此外，可通过选择性溶剂含量控制囊泡尺寸，选择性溶剂含量越高，形成的囊泡越小。本文还进行了Monte Carlo模拟，结果同样表明囊泡尺寸随选择性溶剂含量增加而减小，并阐明了导致囊泡尺寸减小的两个原因；模拟还揭示，囊泡的尺寸均匀性本质上由体系的相互作用焓决定。

Abstract：Vesicle size and size uniformity determine whether the vesicle can realize its full potential on a wide range of biological and biomedical applications. Herein, we reported a simple yet general cosolvent method to directly prepare uniform polymeric vesicles with tunable size ranging from 100 nm to 150 nm formed from the amphiphilic diblock copolymer poly(4-vinylpyridine)-block-polystyrene (P4VP77-b-PS318). The uniform polymeric vesicles can be easily obtained by adding plenty of selective solvent only once into polymer solution and then resting over night. It is found that the uniform vesicles are formed with a fixed size and there is no further fusion between vesicles. The PDI of the vesicles measured by DLS can be as low as 0.03. Moreover, the size of these uniform vesicles can be controlled by the content of selective solvent: the higher the content of selective solvent is, the smaller the vesicles form. Monte Carlo simulation was also performed in this study. The simulation results indicated that the vesicle size indeed decreases with an increase in the content of selective solvent, and two reasons leading to the decrease in vesicle size are elucidated. In addition, the simulations reveal that the size uniformity of the vesicle is essentially determined by the interactive enthalpy of the system.

论文链接：https://doi.org/10.1039/c8nr02901f