作者：Jianhua Lv, Jing Jin, Yuanyuan Han, Wei Jiang
关键字：血液相容性, SEBS, PEG, 环形构象, QCM-D
论文来源：期刊
具体来源：Journal of Biomaterials Science, Polymer Edition, 2019, 30(17), 1670-1685
发表时间：2019年

摘要：以聚多巴胺（PDA）为间隔层，将单端和双端聚乙二醇（PEG）接枝到聚苯乙烯-b-(乙烯-co-丁烯)-b-聚苯乙烯（SEBS）上，制备血液相容性表面。获得了线性和环形构象PEG修饰的SEBS，并利用衰减全反射傅里叶变换红外光谱（ATR-FTIR）和X射线光电子能谱（XPS）确认了结构和组成。PDA和PEG修饰改善了SEBS的血液相容性，在相同接枝长度和质量下，环形PEG的蛋白质抵抗性能优于线性PEG。带耗散功能的石英晶体微天平表明，环形PEG的蛋白质抵抗机制源于其巨大的黏弹性和变形能力。此外，将相同接枝密度的环形和线性PEG接枝到SEBS表面以阐明环形构象的优越性，环形PEG的链长为线性PEG两倍时蛋白质吸附量更低。因此，在SEBS表面固定环形PEG构象是提高SEBS血液相容性的通用且有效的方法。

Abstract：Polyethylene glycol (PEG) with one and two ends are grafted onto poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) via polydopamine (PDA) as a spacer to fabricate a hemocompatible surface. Linear and looped conformational PEGs modified SEBS are obtained, and the structures and compositions are confirmed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The hemocompatibility of SEBS are improved by the modification of PDA and PEG, and the proteins resistances of the looped PEG are superior to that of the linear PEG with the same grafting length and mass. Quartz crystal microbalance with dissipation illustrates that the protein resistance mechanism of looped PEG is because of the huge viscoelasticity and deformation. Furthermore, looped and linear PEGs with the same grafting density are grafted onto SEBS surface to clarify the superiority of the looped conformation. Protein adsorption of looped PEG with twice length of linear PEG shows lower adsorbed amount than the others. Therefore, immobilizing the looped conformation of PEG on SEBS surface is a versatile and efficient way to improve the hemocompatibility of SEBS.

论文链接：https://doi.org/10.1080/09205063.2019.1657621