作者：Min Du, Jianing Zhang, Jing Jin, Wei Jiang
关键字：聚多巴胺, 聚赖氨酸季铵盐衍生物, 光热, 季铵化, 抗菌
论文来源：期刊
具体来源：ACS Biomaterials Science & Engineering, 2023, 9(11), 6103-6111
发表时间：2023年

摘要：具有优异弹性、热塑性和生物稳定性的聚苯乙烯-b-(乙烯-co-丁烯)-b-聚苯乙烯（SEBS）在医疗领域引起广泛关注。然而，细菌容易黏附在疏水SEBS表面，导致医疗器械相关感染。本文通过聚多巴胺（PDA）沉积和表面接枝技术对SEBS进行改性，制备SEBS-PDA-聚赖氨酸季铵盐衍生物（PLQ）抗菌表面以解决细菌感染问题。PDA作为中间层并具有优异光热效应，接枝聚合物PLQ具有抗菌季铵阳离子基团，与PDA协同杀菌。激光照射下SEBS-PDA-PLQ表面几乎完全抑制细菌生长，表面细菌存活率为0.05%。SEBS-PDA-PLQ表面的优异抗菌活性归因于PDA光热性能和PLQ季铵阳离子功能基团的协同作用。此外，SEBS-PDA-PLQ膜具有良好的亲水性、抗蛋白质吸附能力、化学稳定性和生物相容性。这种无抗生素抗菌方法在解决医疗器械相关感染的实际应用方面具有巨大潜力。

Abstract：Poly(styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) with eminent elasticity, thermoplastic ability, and biological stability has aroused great interest in the medical area. However, bacteria can easily adhere to the hydrophobic SEBS surface to cause medical device-related infections. In this work, SEBS is modified to prepare the SEBS-polydopamine (PDA)-poly(lysine) quaternary ammonium derivative (PLQ) antibacterial surface by PDA deposition and surface grafting techniques to solve bacterial infections. PDA is used as an intermediate layer and presents an excellent photothermal effect. The grafted polymer PLQ has antimicrobial quaternary ammonium cation groups, which plays synergistic bactericidal therapy with PDA. The SEBS-PDA-PLQ surface almost totally suppresses the growth of bacteria with a surface bacterial survival rate of 0.05% under laser irradiation. The outstanding antibacterial activity of the SEBS-PDA-PLQ surface is attributed to the synergistic effects of the photothermal performance of PDA and quaternary ammonium cationic functional groups of PLQ. In addition, the membrane SEBS-PDA-PLQ shows good hydrophilicity, antiprotein adsorption ability, chemical stability, and biocompatibility. This antibiotic-free antimicrobial approach has great potential for practical application in solving infections associated with medical devices.

论文链接：https://doi.org/10.1021/acsbiomaterials.3c01135