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Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles
作者:Zhong Luo, Kaiyong Cai, Yan Hu, Jinghua Li, Xingwei Ding, Beilu Zhang, Dawei Xu, Peng Liu
关键字:mesoporous silica
论文来源:期刊
具体来源:Advanced Materials, 2012, 24, 431–435
发表时间:2012年

A novel redox responsive controlleddrug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.