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【Comp Sci Tech】Antibacterial and biocompatible properties of polyurethane nanofiber composites with integrated antifouling and bactericidal components
作者:Hengchong Shi, Haiyu Liu, Shifang Luan, et al.,
关键字:TPU nanofiber composites, Ultrasonication, Antibacterial, Wound dressing
论文来源:期刊
具体来源:Composites Science and Technology 127 (2016) 28-35
发表时间:2016年

A facile, low-cost and time-saving method was proposed to prepare antibacterial polyurethane-g-polyethylene

glycol (TPU-g-PEG) nanofiber composite by anchoring silver nanoparticles (AgNP) onto nanofibers

via ultrasonication assistance. Firstly, antifouling PEG as bacteria-repelling component was

chemically grafted onto TPU nanofibers through UV photo-graft polymerization to obtain TPU-g-PEG

nanofibers; then AgNP as bactericidal component were immobilized onto the TPU-g-PEG nanofibers

under the assistance of ultrasonication. Even if the nanofibers were immersed into PBS solution and

incubated for 7 days, the released content of AgNP characterized by ICP-MS was 2.688 mg which was

much lower than that of reference reported method. The TPU-g-PEG/Ag nanofiber composites exhibited

excellent hemocompatibility, including suppression of platelet and red blood cell adhesion, the lower

hemolysis ratios, and the higher blood clotting index. Importantly, the as-prepared nanofiber composites

performed better antibacterial properties in vitro assays employing gram negative and positive strains,

because of the bacterial resistance of the grafted PEG and the bactericidal effect of silver. 

has significant potential for the development of infection-resistant wound dressing.