作者：Yuanwei Su, Jing Dang, Haitao Zhang, Yingyi Zhang, and Wei Tian*
关键字：Supramolecular Host-Guest Interaction, Drug Release, Porous Polymer Films
论文来源：期刊
具体来源：Langmuir 2017, 33, 7393-7402
发表时间：2017年

    Drug delivery systems based on stimuli-responsive porous polymer films (PPFs) have been extensively investigated because of their many advantages. However, the ability to adjust the drug release from PPFs is not always perfect, and at times, it cannot satisfy real-world requirements. In this paper, supramolecular host?guest interactions were harnessed to overcome the difficulties associated with adjustable release from these systems by incorporating host molecules into the pore walls of thermoresponsive PPFs. β-Cyclodextrin-functionalized porous amphiphilic block copolymer films (β-CD-PBCPFs) with controllable pore parameters, high homogeneity, and large areas were prepared by combining the self-assembly and breath-figure methods. Drug-loaded β-CD-PBCPFs displayed thermoresponsive release behavior, which could be tuned by increasing the β-CD content in phosphate-buffered saline. The release was governed by the host-guest interactions of the β-CD moieties and drug molecules. The concept of host?guest interactionenhanced adjustable release could be applied to different drug molecules, such as doxorubicin and metronidazole.

全文链接：

http://pubs.acs.org/doi/abs/10.1021/acs.langmuir.7b01502