writer：Tan, JJ; Liu, RG*; Huang Y
keywords：stimuli sensitive, HPC, nanogels
source：会议
specific source：Abstracts of Papers of the American Chemical Society Volume: 240 Published: Aug 2010
Issue time：2010年

A new type of cellulose derivative is synthesized by means of conjugating cysteamine to the hydroxypropyl cellulose (HPC). The thiolated HPC (HPC-SH) not only maintains the thermosensitivity of HPC but also has reduction-sensitivity. Nanogels can be fabricated by the self-association for HPC-HS in the solution at 45 ^oC and then oxidation of thiol groups to disulfide bonds. The crosslinking degree of the nanogels can be controlled by the substitution degree of thiol groups (-SH) in the thiolated HPC. The hydrodynamic radius of the nanogels can be tuned by adjusting the degree of crosslinking and the concentration of the initial thiolated HPC solution in the self-associating process. The hydrodynamic radius of the nanogels are varied with the temperature and the dissociation process can be happened by adding the reducing agent dithiothreitol (DTT). The dual-stimuli sensitive nanogels may have potential applications in controlled release and transfer switch device and sensors.