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车超越工作发表在ACS Biomater Sci Eng并入选ACS Editors’ Choice

Abstact: Uncontrolled hemorrhage is the leading factor causing death in military trauma and clinical practice and is usually accompanied with bacterial infection. The fabrication of a functional hemostatic sponge for combating bacteria is of vital importance. Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to have a remarkable bactericide effect. However, PHMB after use might have a toxic effect on humans. Herein, a powerful surface-adaptive, on-demand antibacterial hemostatic sodium alginate/gelatin sponge is fabricated by sequential spray-assisted layer-by-layer assembly of PHMB and hyaluronic acid (HA). The HA upper layer could endow the coating surface with better biocompatibility under physiological conditions. Once bacteria invade, the secreted hyaluronidase could degrade the upper HA layer, and then the exposed PHMB layer could kill the bacteria. The coated sponge shows excellent biocompatibility, as negatively charged HA can prevent the exposure of bactericidal PHMB. Moreover, the coated sponge exhibited excellent hemostatic properties in vitro and in vivo by aggregating and activating blood cells. Our strategy provides a novel approach to the design of surface-adaptive and on-demand bactericidal coatings on the surface of hemostatic sponges, which has the advantage of avoiding infection complications during hemostasis.

ACS Editors’ Choice是美国化学学会(ACS)于2014年1月1日推出的一项扩大刊物影响力的举措。该服务每天从ACS开办的51种同行评议期刊中选取一篇具有重大科学意义的优秀论文,入选率低于1%,并成为向公众永久免费开放的浏览资源,且无需论文作者付费。ACS Editors’ Choice的文章发放到ACS的首页上,以图片形式滚动播放7天,相当于每天的头条。ACS旗下每个期刊的编辑团队要为“ACS Editors’ Choice”窗口推荐论文,推荐选定的论文必须是每个杂志所有论文中的极品佳作。