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Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin
writer:Rong-Min Wang, Jing-Feng SONG, Yu -Feng He,Juan-Juan Mao,Yan Li
keywords:Chitooligosaccharide-5-fluorouracil, BSA, fluorescence spectroscopy.
source:期刊
specific source:Chinese Chemical Letters Vol. 17, No. 11, pp 1495-1498, 2006
Issue time:2006年

The interaction between chitooligosaccharide-5-fluorouracil (COS-SFU) and bovine serum albumin (BSA) was studied by fluorescence spectroscopy.  It was found that an energy transfer between COS-SFU and BSA had been occurred.  The binding constants were calculated, k298k=1.175x104 Lmol-}.  Based on the mechanism of  energy transfer of dipole-dipole interaction between the donor and acceptor, the distance between BSA and COS-5FU was determined.