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Methoxy poly(ethylene glycol)-b-poly(octadecanoic anhydride)-b-methoxy poly(ethylene glycol) amphiphilic triblock copolymer nanopartiles as delivery vehicles for paclitaxel
writer:Jinfeng Xing et al.
keywords:Amphiphilic triblock copolymers; Poly(ethylene glycol); Poly(octadecanoic anhydride); Nanoparticle; Paclitaxel
Issue time:2009年

A series of amphiphilic triblock copolymers, methoxy poly(ethylene glycol)-b-poly(octadecanoic anhydride)-b-methoxy poly(ethylene glycol) (mPEG-b-POA-b-mPEG), were prepared via melt polycondensation of methoxy poly(ethylene glycol) (mPEG) and poly(octadecanoic anhydride) (POA). mPEG-b-POA-b-mPEG were characterized by FTIR, 1H-NMR, GPC, DSC and XRD. Stable drug-loaded mPEG-b-POA-b-mPEG nanoparticles (NPs) with sphere morphology and narrow size polydispersity index were prepared by nanoprecipitation technique with paclitaxel as the model drug. In vitro release behaviors of drug-loaded NPs present biphasic process and the release mechanism of each phase is zero order drug release. In vitro cytotoxicity tests investigated by MTT assay indicate that mPEG-b-POA-b-mPEG are non-toxic to normal mouse lung fibroblast cells (L929). According to this study, mPEG-b-POA-b-mPEG NPs could serve as suitable delivery vehicles for paclitaxel and other hydrophobic drugs.