writer：Zhao Yun, Liu Bei, Bi Hongwei, Yang Jinjun, Li Wei, Liang Hui, Liang Yue, Jia Zhibin, Shi Shuxin, Ch
keywords：聚乳酸， 氧化镁， 体外降解
source：期刊
specific source：Internatioanl Journal of Molecular Sciences
Issue time：2018年

In this study, composite films of stearic acid–modified magnesium oxide whiskers

(Sa–w-MgO)/poly-L-lactic acid (PLLA) were prepared through solution casting, and the in vitro degradation properties and cytocompatibility of the composites with different whisker contents were investigated. The results showed that the degradation behavior of the composite samples depended significantly on the whisker content, and the degradation rate increased with the addition of MgO content. Furthermore, the degradation of the composites with higher contents of whiskers was influenced more severely by the hydrophilicity and pH value, leading to more final weight loss, but the decomposition rate decreased gradually. Furthermore, the pH value of the phosphate buffer solution (PBS) was obviously regulated by the dissolution of MgO whiskers through neutralization of the acidic product of PLLA degradation. The cytocompatibility of the composites also increased

remarkably, as determined from the cell viability results, and was higher than that of PLLA at the chosen whisker content. This was beneficial for the cell affinity of the material, as it notably led to an enhanced biocompatibility of the PLLA, in favor of promoting cell proliferation, which significantly improved its bioactivity, as well.