writer：Yang Jinjun, Cao Xiuxiang, Zhao Yun, Wang Liang, Liu Bei, Jia Junping, Liang Hui, Chen Minfang
keywords：Poly(L-lactide); magnesium oxide nanoparticle, modification, in vitro
source：期刊
specific source：Journal of Biomaterials Science, Polymer Edition
Issue time：2017年

The modified MgO nanoparticles (m-MgO-NPs) by a copolymer

containing the malic acid and low molecular weight poly(L-lactide)

(poly(L-lactide-co-malic acid), PLMA) have been successfully

prepared. MgO nanoparticles (MgO-NPs) were coated by the PLMA

and m-MgO-NPs were uniformly dispersed in the PLLA matrix to a

novel biocomposite material (PLLA/m-MgO-NPs) with more excellent

interface bonding and uniformer dispersion, compared to the

PLLA/MgO-NPs. Compared to neat PLLA and PLLA/MgO-NPs film,

the m-MgO-NPs not only shown the obvious neutralization effect

on the acidic solution in the degradation of the PLLA and better

hydrophilicity, but also exhibited the higher cell viability and decrease

the toxicity to the cell in the degradation process of PLLA in vitro.

In addition, m-MgO-NPs also reduced the degradation rate of the

PLLA. The mechanisms for the excellent dispersion of nanoparticles,

enhanced pH stability, reduced degradation rate of the PLLA and the

cell viability in vitro in the case of PLLA/m-MgO-NPs have also been

proposed and discussed in detail.