作者：Chen Xiyi, Gu Haifeng, Yang Jinjun, Wu Sudong, Liu Jun, Yang Xi, Chen Qixian
关键字：polymeric micelle, PEGylation, cyclic RGD, mRNA delivery, endosome escape
论文来源：期刊
具体来源：ACS Applied Materials & Interfaces
发表时间：2017年

A facile poly(ethylene glycol) (PEG) detachment

scheme was utilized to control the PEGylation degree of the

polymeric micelles. The performance of cyclic Arg-Gly-Asp (cRGD)

as a targeted moiety was studied on a class of polymeric micelles with

various PEGylation degrees, revealing that the specific cRGDmediated

cell affinity, thus the cellular uptake and implicated privileges

including the ligand-specified favorable intracellular trafficking and

consequent favorable biofunctions, was prominent for the polymeric

micelles with high PEGylation degree. These results endow important

information and implications for the design and development of

targeted nanomedicine, particularly the delivery of vulnerable

biological compounds.