作者：Bin Liu, Wei Zhang, Qingyun Zhang, Han Zhang, JingYu, and Xinlin Yang*
关键字：Controllable structure, Hollow porous magnetic microsphere
论文来源：期刊
具体来源：J. Colloid Interface Sci., 375 (1), 70-77 (2012). DOI: 10.1016/j.jcis.2012.02.023
发表时间：2012年
Hollow porous magnetic microspheres with strong magnetization and controllable structure were prepared via a facile electrostatic self-assembly of the positively charged Fe3O4 nanoparticles onto the surface of the negatively charged poly(N,N0-methylenebisacrylamide-co-methacrylic acid) (P(MBAAmco-MAA)) microspheres with subsequent removal of the polymer core through calcination at high temperature. The shell thickness was facilely tuned through the ratio between Fe3O4 and polymer, and the void space was conveniently changed through the size of polymer microspheres. The hollow magnetic microspheres possessed high saturation magnetization value (51.38 emu/g) and porous structure with
high specific surface area (108.04 m2/g). Based on these properties, the drug loading and release behaviors were investigated, which indicated that the hollow magnetic microspheres exhibited a controlled release process.