Title: Substrate-mediated gene silencing: The synergistic roles of nanofibertopography and sustained biochemical signaling in neural tissue engineering

Speaker: Dr. CHEW Sing Yian(周欣燕), Associate professor

School of Chemical & Biomedical Engineering

Nanyang Technological University, Singapore

Moderator: Professor DapingQuan, 全大萍教授

Time: ,December 16, 2013 (Monday)

Venue: A402, Fengsheng Hall, South Campus, SYSU

Abstract:

Nanofibersubstratesclosely mimic of the architecture of the natural extracellular matrix. These constructs represent a novel class of materials in regenerative medicine. Fibrous topographical cues can direct cellular response and stem cell fate. Combined with the incorporation of biochemicals such as small-interfering RNAs, these substrates provide synergistic topographical and biochemical cues to seeded cells. We will discuss our recent findings on the roles of nanofiber topography on nerve regeneration. The advantages ofsustained scaffold-mediated gene silencing in directing stem cell neuronal commitment and enhancing in vivo tissue-implant integration will also be discussed.