作者：张黎明等//Zhang, L. M.; et al
关键字：天然大分子，生物大分子, 功能材料, 杂化材料 // Natural macromolecules, Biomacromolecules, Functional materials, Hybrid materials
论文来源：期刊
发表时间：2016年
*Corresponding author/通讯作者. #These authors contributed equally to this work/共同第一作者.
Refereed Scientific Papers / 学术杂志发表论文
[309] Yin, Y. T.#; Fu, C. P.#(傅超萍); Li, M.; Li, X. P.; Wang, M. Y.; He, L.; Zhang, L. M.*(张黎明); Peng, Y.* A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment. Materials Science and Engineering C-Materials for Biological Applications, 2016, 67: 159-169. DOI: 10.1016/j.msec.2016.05.012 (SCI)
[308] Yang, H. K. #(杨惠康); Qi, M.#; Mo, L.; Yang, R. M.; Xu, X. D.; Bao, J. F.; Tang, W. J.; Lin, J. T.(林坚涛); Zhang, L. M.*(张黎明); Jiang, X. Q.* Reduction-sensitive amphiphilic dextran derivatives as theranostic nanocarriers for chemotherapy and MR imaging. RSC Advances, 2016, 6:114519-114531. DOI: 10.1039/c6ra22373g (SCI)
[307] Liu, Y.#; Deng, L. Z.#(邓立志); Sun, H. P.; Xu, J. Y.; Li, Y. M.; Xie, X.; Zhang, L. M.*(张黎明); Deng, F. L.* Sustained dual release of placental growth factor-2 and bone morphogenic protein-2 from heparin-based nanocomplexes for direct osteogenesis. International Journal of Nanomedicine, 2016, 11: 1147-1158. DOI: 10.2147/ijn.s100156 (SCI)
[306] 刘日钊, 张娟, 刘涛, 符小艺, 张黎明(Zhang, L. M.), 谢民强*. 叶酸靶向共载TFPI-2及顺铂磁性纳米复合物的制备及其对鼻咽癌HNE一1细胞的靶向性和体外抑制效应[Preparation of folate-targeted
magnetic nanocomposites loaded wjth TFPI-2 plasmid and cisplatin and evaluation
of its targeting and inhibitory effect on nasopharyngeal carcinoma HNE-1 cells in vitro]. 中华医学杂志 / National
Medical Journal of China, 2016, 96(25), 2023-2030.
[305] 王芬*，庞家栋，张黎明(Zhang, L. M.) 多功能纳米材料CDPF/CDP运载AEG-1 siRNA抑制骨肉瘤细胞增殖和侵袭能力的研究[EB/OL]. 北京：中国科技论文在线 / Chinese Science and Technology Papers online [2016-11-11]. http://www.paper.edu.cn/releasepaper/content/201611-169.
摘要：目的 探讨多功能纳米材料CDPF和CDP运载AEG-1 siRNA进入骨肉瘤细胞能力以及其对细胞增殖、侵袭能力的影响。方法 通过体外细胞瞬时转染实验将CDPF/AEG-1 siRNA或CDP/AEG-1 siRNA运载入143B细胞，用Western-blot检测AEG-1 蛋白水平的变化，分别用MTT法和侵袭实验检测转染复合物对143B细胞增殖能力和侵袭能力的影响。结果 CDPF和CDP成功的将AEG-1 siRNA运载至143B细胞，与对照组比较，AEG-1蛋白水平显著降低，下调AEG-明显抑制143B细胞的增殖和侵袭能力，且CDPF比CDP具有更好的优势。结论 CDP可作为有效的新型基因转染载体，叶酸的接入可提高其效率。