writer：Zhen-Ni Lu, Lei Wang, Xuan Zhang,* Zhi-Jia Zhu
keywords：Fluorescent chemosensor; Cd2+; 8-Hydroxylquinoline; Benzothiazole; Fluorescence imaging
source：期刊
specific source：Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2019, 213, 57-63.
Issue time：2019年
A 8-hydroxylquinoline-benzothiazole conjugate (HQ-BT) was facilely synthesized by two steps with >60% total reaction yield. The HQ-BT showed a weak fluorescence that could be strongly enhanced by coordination with various metal ions such as Al3+, Cd2+, Zn2+ in methanol containing 1% water. Interestingly, the selectivity toward Cd2+ was achieved by increasing water fraction to 30% aqueous methanol solution. Thus, the HQ-BT was developed as a new and selective fluorescent chemosensor for Cd2+ in aqueous solution with a broad pH region 4–12. A good linear relationship between the fluorescence intensity and the Cd2+ concentration was found in the range of 0–5?μM with a detection limit of 0.1?μM (S/N?=?3). It was also succesfully used for fluorescence imaging of Cd2+ in living cells.