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  • Stimulus responsive nanogels for drug delivery
  • 来源:查刘生研究员个人网站 2015-07-26
  • Stimulus responsive nanogels are polymeric nanoparticles which are capable of responding to external
    stimuli by changing their physico-chemical properties, such as volume, water content, refractive index,
    permeability, and hydrophilicity–hydrophobicity. Compared with other polymer nanoparticles used
    for drug delivery, stimulus responsive nanogels are noted for their ability to encapsulate bioactive
    drugs, their high stability for prolonged circulation in the blood stream, and their controlled release and
    site-specific targeting of loaded drugs modulated by environment stimuli. Particularly, the application
    of stimulus responsive nanogels provides an interesting opportunity for drug delivery in which the
    delivery system becomes an active participant, rather than a passive carrier, in the optimization of
    disease therapy. In this article, the authors review the recent developments in the preparation and
    application in drug delivery of stimulus responsive nanogels which can respond to small temperature
    and pH changes, light, magnetic field, biomolecule recognition (specifically glucose responsive nanogels
    for insulin delivery), and multi-responsive nanogels. The limitations and future improvements of
    stimulus responsive nanogels are also discussed.
  • [来源:中国聚合物网]
  • 了解更多请进入: 查刘生研究员个人网站
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