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  • Dual stimuli responsive hollow nanogels with IPN structure for temperature controlling drug loading and pH triggering drug release
  • 来源:查刘生研究员个人网站 2015-07-26
  • nanogels with an interpenetrating polymer network (IPN) structure
    based on a poly(acrylic acid) (PAA) network and a poly(N-isopropylacrylamide)
    (PNIPAM) network (PNIPAM/PAA IPN
    hollow nanogels) were fabricated by a two-step sequential colloidal
    template polymerization and subsequent removal of the cavity
    templates. Their chemical composition, IPN structure and hollow
    structure were verified by Fourier transformation infrared spectroscopy
    (FTIR) and transmission electron microscopy (TEM),
    respectively. pH and temperature dependent particle sizes measured
    by dynamic light scattering indicated that the hollow nanogels have
    both pH and temperature dual stimuli responsive properties. Isoniazid
    (INH), an antitubercular drug, was loaded into PNIPAM/PAA
    IPN hollow nanogels by controlling the equilibrium temperature
    ensuring it is lower than their volume phase transition temperature,
    so that the drug loading capacity can reach 668 mg INH per gram of
    the hollow nanogel. It can be seen from the TEM results that the
    encapsulated INH is mainly located in the cavities of the hollow
    nanogels. In vitro drug release studies showed that the INH loaded
    PNIPAM/PAA IPN hollow nanogels possess distinct acid triggered
    drug release behavior, which may make them suitable for a stomachspecific
    drug delivery system.
  • [来源:中国聚合物网]
  • 了解更多请进入: 查刘生研究员个人网站
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