作者：Xiuli Hu, Rui Wang, Jun Yue, Shi Liu, Zhigang Xie and Xiabin Jing
关键字：conjugates
论文来源：期刊
具体来源：J. Mater. Chem., 2012,22, 13303-13310
发表时间：2012年
Multifunctional micelles were successfully prepared by co-assembling a Doxorubicin-conjugated copolymer (mPEG-b-P(LA-co-ME/Dox), for antitumor properties) and a Rhodamine B-conjugated copolymer (mPEG-b-P(LA-co-ME/RhB), for imaging) with a folic acid (FA)-conjugated copolymer (FA-PEG-b-PLA, for targeting), respectively. DLS showed that the sizes of these micelles were in the range of 150–300 nm. Fluorescent imaging analysis based on the RhB signals of the isolated visceral organs showed that the micelles with or without FA moieties were mainly accumulated in the liver and in the tumor from 2 h post drug administration, maximized at ca. 6 h, and decayed afterwards. More FA-carrying micelles were accumulated in the tumor for a longer time compared to the micelles without FA moieties. Dox-containing micelles were used for tumor inhibition experiments in vivo and the results showed that the micelles with FA moieties exhibited better antitumor ef?cacy than those without FA and free Dox.