Targeting and anti-tumor effect of folic acid-labeled polymer–Doxorubicin conjugates with pH-sensitive hydrazone linker
作者:Xiuli Hu, Rui Wang, Jun Yue, Shi Liu, Zhigang Xie and Xiabin Jing
关键字:conjugates
论文来源:期刊
具体来源:J. Mater. Chem., 2012,22, 13303-13310
发表时间:2012年
Multifunctional micelles were successfully prepared by co-assembling a Doxorubicin-conjugated
copolymer (mPEG-b-P(LA-co-ME/Dox), for antitumor properties) and a Rhodamine B-conjugated
copolymer (mPEG-b-P(LA-co-ME/RhB), for imaging) with a folic acid (FA)-conjugated copolymer
(FA-PEG-b-PLA, for targeting), respectively. DLS showed that the sizes of these micelles were in the
range of 150–300 nm. Fluorescent imaging analysis based on the RhB signals of the isolated visceral
organs showed that the micelles with or without FA moieties were mainly accumulated in the liver and
in the tumor from 2 h post drug administration, maximized at ca. 6 h, and decayed afterwards. More
FA-carrying micelles were accumulated in the tumor for a longer time compared to the micelles without
FA moieties. Dox-containing micelles were used for tumor inhibition experiments in vivo and the results
showed that the micelles with FA moieties exhibited better antitumor ef?cacy than those without FA
and free Dox.