Fangfang Chen, Weifeng Zhao,Jingjing Zhang, Jie Kong*,Magnetic Two-dimensional Molecularly Imprinted Materials for Recognition and Separation of Proteins, Phys. Chem. Chem. Phys., 2016, 18: 718-725

链接：http://pubs.rsc.org/en/content/articlelanding/2014/CP/C5CP04218F#!divAbstract

摘要：Surface molecular imprinting for proteins is an emerging cross field of molecular imprinting engineering and functional materials. In this contribution, we report a novel design of magnetic two-dimensional molecularly imprinted polymers (2D-MIPs) for high recognition and separation of proteins. The bovine serum albumin-surface-imprinted polydopamines were prepared on the surfaces of magnetic Fe3O4–graphene oxide hybrid to form magnetic 2D-MIPs for proteins. The 2D Fe3O4–graphene oxide substrate possesses a dominant surface-to-volume ratio in comparison to 3D spherical substrate with the same volume. These materials are sensitive to a magnetic field and can be easily separated using an external magnet. The binding experiment results of bovine serum albumin on magnetic 2D-MIPs and real sample analysis demonstrated high recognition specificity, selectivity, accessibility and convenient separation of 2D-MIPs for template protein. The design and synthesis of magnetic 2D-MIPs provide a new perspective for the surface molecularly imprinted materials with potential in recognition and separation of proteins.