曾宪顺 博士，研究员，博士生导师，教育部新世纪优秀人才。主要从事分子生物信息材料与物理相关的荧光分子传感器、荧光分子探针的研究。在Chem. Eur. J.; Chem. Commun.; Org. Ltt.; J. Org. Chem.；Organometallics; Inorg. Chem.; J. Mater. Chem.; Adv. Funct. Mater.; Org. Biomol. Chem.; Tetrahedron Lett.等国内外期刊发表SCI收录论文100余篇，其中SCI影响因子大于3.0的论文60多篇，被SCI源论文正面引用近2000次，申报发明专利12项，2006年获天津市自然科学二等奖1项；2009年入选“教育部新世纪优秀人才支持计划人选”；2012年度入选天津市“131”创新型人才培养工程第一层次人选。
2001年获得南开大学理学博士学位；2001年7月-2005年6月在南开大学任讲师、副教授；2003年7月-2004年8月在Université du Havre/巴黎大学(V)法国国家研究中心(CNRS)做博士后；2004年9月-2006年8月在英国杜伦大学做EPSRC博士后；2006年9月-2007年6月在巴黎大学(V)法国国家研究中心（CNRS）做博士后；2007年7月至今天津理工大学任特聘教授；2008年7月-2008年9月在巴黎大学(V)法国国家研究中心（CNRS）做访问教授；2010年受聘哈尔滨工业大学材料科学与工程学院外聘博士生导师。
课题组研究领域：
课题组的研究工作主要围绕于材料科学、生物医学、信息材料科学，以材料分子与结合目标之间作用产生的光/电信息为主要研究对象。开展包括荧光分子传感器、电化学分子传感器、生物荧光探针等领域的研究工作。通过对有机、高分子、纳米等荧光或电活性探针材料的优化设计，采用荧光成像技术、荧光光谱分析、电化学分析等信号分析手段来研究探针材料与实际医药分析检测、活细胞或活体动物之间作用时产生的光电信号，并通过对信号的分析处理实现对活体离子检测评价、癌症等重大疾病的早期检测。
主要研究方向包括：
1. 化学和生物荧光小分子传感探针。
2. 靶向和智能荧光小分子生物探针。
1）靶向荧光小分子生物探针
通过对探针材料的靶向设计，开发发光性能稳定、生物相融强、靶向选择性高的生物荧光探针材料，并探索在肿瘤早期检测等领域的应用。
2）智能荧光小分子生物探针
通过荧光共振能量转移原理（FRET）或生物分子靶原理设计针对目标检测物的各种智能荧光小分子生物探针。
3. 光/电聚合物生物传感探针。
研究生人才培养：
课题组从成立以来已培养硕士研究生18人，博士研究生3人，分别就业于中科院，高校，大中型生物医药企业和光电子企业；目前有在读博士研究生7人，在读研究生7人。
1.课题组每年招收化学和生物专业的硕士研究生2-3人;
2. 课题组每年招收化学专业或生物专业的博士研究生1-2人。
欢迎有志于生物医用材料的学生报考课题组的硕士研究生和博士研究生。
主持完成项目:
1. 主持国家自然科学基金《荧光信号释放受分子逻辑门机制控制的新型靶向智能探针及荧光标记成像》21272172, 2013.1-2016.12
2. 主持国家自然科学基金《内部固有金属催化位点的笼状聚集体的构建及其对烷烃氧化反应的催化性能研究》20972111, 2010-2012.
3. 主持教育部新世纪优秀人才支持计划《靶向红外荧光探针及其在癌症等重大疾病检测中的应用》NCET-09-0894, 2009-2011.
4. 主持天津市自然科学基金重点项目《双控制型智能荧光探针与肿瘤荧光标记成像》12JCZDJC21000, 2012.4-2015.3.
5. 主持完成天津市自然科学基金《基于新型杯[6]芳烃衍生物的全光子逻辑门器件》08JCYBJC26700, 2008-2010.
6. 主持完成教育部基金《基于新型杯[6]芳烃衍生物的全光子输入/输出分子逻辑门系统》(教外司留[2008]101号), 2008-2011.
7. 主持完成南开大学国家重点实验室2008年-2012年连续5期开放基金《基于杯[6]芳烃的荧光受体分子器件的构建及性能研究》, 2008.1-2008。12.
专利：
1. 一种具有核-壳结构的有机分子探针材料及其制备方法，发明专利公开号 CN101602942A
2. 一种含给电子基团半菁蓝素温敏分子光学探针的制备方法, 发明专利申请号 2013100220191
3. 一种含吸电子基团半菁蓝素温敏分子光学探针的制备方法，发明专利申请号 2013100218524
4. 一种半菁蓝素硼酸分子荧光探针及其制备方法和应用，发明专利申请号2012105743088
5. 一种用于检测次氯酸根的分子荧光探针及其制备和应用，发明专利申请号2012105741631
6. 一种通过阴离子诱导形成聚集体的阴离子荧光探针， 发明专利申请号201310335468.1
获奖和荣誉称号:
2009年，教育部新世纪优秀人才支持计划人选，中华人民共和国教育部。NCET-09-0894
2006年，天津市自然科学奖二等奖，《超分子化学基础研究—识别、组装和化学传感》2006ZR-2-002-R3，天津市人民政府。
发表论文:
发表论文:
Qing Wang, Xiaojie Jiao, Chang Liu, Song He, Liancheng Zhao and Xianshun Zeng, A rhodamine-based fast and selective fluorescent probe for monitoring exogenous and endogenous nitric oxide in live cells, J. Mater. Chem. B, 2018, Advance Article, http://dx.doi.org/10.1039/C8TB00646F
C. Zhang, J. Li, X. Zeng, Z. Yuan and N. Zhao, Graphene quantum dots derived from hollow carbon nano-onions, Nano Research, 2018, 11, 174-184.
Dasheng Zheng, Xiaoying Qiu, Chang Liu, Xiaojie Jiao, Song He, Liancheng Zhao and Xianshun Zeng, Synthesis and bioapplication of a highly selective and sensitive fluorescent probe for HOCl based on a phenothiazine–dicyanoisophorone conjugate with large Stokes shift, New J. Chem., 2018, 42, 5135-5141, http://dx.doi.org/10.1039/C8NJ00279G
C. Liu, X. Jiao, Q. Wang, K. Huang, S. He, L. Zhao, X. Zeng, Unique Rectilinearly π-Extended Rhodamine Dye with Large Stokes Shift and Near-Infrared Fluorescence for Bioimaging, Chem. Commun. 2017, 53, 10727-10730 http://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc06220f#!divAbstract
H. Tang, X. Zhang, X. Zeng, Z. Zhou, Synthesis of novel naphtho[2,3-b]furan-4,9-diones bearing 2-aminopyridine moiety under aerobic condition and their absorption behaviors, Tetrahedron, 2017, 73, 6962-6968 http://www.sciencedirect.com/science/article/pii/S004040201731089X
K. Huang, X. Jiao, C. Liu, Q. Wang, X. Qiu, S. He, L. Zhao and X. Zeng, Synthesis of a novel π-extended hybrid rhodamine dye with far-red fluorescence emission and its application in bioimaging, Dyes and Pigments, 2017, 145, 561-569
C. Liu, X. Jiao, S. He, L. Zhao and X. Zeng, Fluorescent probe for hypochlorous acid detection with high selectivity and sensitivity and its application for lysosomal-targetable real-time biological imaging, Talanta 2017, 174, 234-242
K. Huang, Y. Yue, X. Jiao, C. Liu, Q. Wang, X. Qiu, S. He, L. Zhao and X. Zeng, Fluorescence regulation of 4-aminobenzofluoran and its applications for Cu2+-selective fluorescent probe and bioimaging, Dyes and Pigments, 2017, 143, 379-386.
C. Liu, X. Jia, S. He, L. Zhao, X. Zeng, Highly selective and sensitive fluorescent probe for Cu2+ based a novel naphthalimide-rhodamine platform and its application in live cell imaging, Org. Biomol. Chem. 2017, 15, 3947-3954
X. Jiao, C. Liu, Q. Wang, K. Huang, S. He, L. Zhao and X. Zeng, Fluorescence probe for hypochlorous acid in water and its applications for highly lysosome-targetable live cell imaging, Anal. Chim. Acta, 2017, 969, 49-56.
K. Huang, S. He, X. Zeng, A fluoran-based fluorescent probe via a strategy of blocking the intramolecular photoinduced electron transfer (PET) process, Tetrahedron Lett. 2017, 58, 2004-2008
K. Huang, X. Jiao, C. Liu, Q. Wang, X. Qiu, D. Zheng, S. He, L. Zhao, X. Zeng, Highly selective and sensitive fluorescent probe for mercury ions based on a novel rhodol-coumarin hybrid dye. Dyes and Pigments, 2017,142, 437-446
X. Qiu, X. Jiao, C. Liu, D. Zheng, K. Huang, Q. Wang, S. He, L. Zhao, X. Zeng, A selective and sensitive fluorescent probe for homocysteine and its application in living cells, Dyes and Pigments, 2017, 140, 212-221
C. Liu, X. Jiao, S. He, L. Zhao and X. Zeng, A reaction-based fluorescent probe for the selective detection of formaldehyde and methylglyoxal via distinct emission patterns, Dyes and Pigments, 2017, 138, 23-29
M. Wang, W. Li, C. You, Q. Wang, X. Zeng and M. Chen, Triboelectric nanogenerator based on 317L stainless steel and ethyl cellulose for biomedical applications, RSC Adv., 2017, 7, 6772-6779
J. Qin, H. Yao, S. He and X. Zeng, Design and synthesis of a rhodol isomer and its derivatives with high selectivity and sensitivity for sensing Hg2+ and F- in aqueous media, RSC Adv., 2016, 6, 75570-75577.
J. Su, S. Huang, S. He and X. Zeng, Sensitive and Selective Fluorescent Chemosensors Combining Multiple PET Processes for Ag+ Sensing, Chem. Res. Chin. Univ., 2016, 32, 20-27.
Zhang X.; Zeng X.; Zhou Z., Synthesis of stereodefined multi-functionalized tetrasubstituted olefins via a catalyst-free oxidative coupling strategy and their application for hpochlorite anion detection, ChemistrySelect, 2016, 1, 6485-6489
L. Liang, L. Zhao and X. Zeng, Synthesis, optical, and chemical properties of a π-extended rhodol derivative and its derivatives with selectivity and sensitivity for sensing Hg2+ in aqueous media, RSC Adv., 2016, 6, 85165-85172
米小龙 焦晓洁 刘畅 何松 曾宪顺, 基于罗丹明荧光信号报告基团的细胞通透性铜离子荧光探针, 高等学校化学学报, 2016, 37, 1784-1791.
X. Zhang, Q. Liu, X. Zeng, J. Sui, W. Cai, H. Wang, Y. Feng, Microstructure, mechanical properties and shape memory effect of Ni–Mn–Ga–B high-temperature shape memory alloy, Intermetallics, 2016, 68, 113-117
Liang L., Liu C., Jiao X., Zhao L. and Zeng, X. A highly selective and sensitive photoinduced electron transfer (PET) based HOCl fluorescent probe in water and its endogenous imaging in living cells. Chem. Commun., 2016, 52, 7982-7985
Yao H., Chang L., Liu C., Jiao X., He S., Liu H., Zeng X., A Novel Styryldehydropyridocolinium Homodimer: Synthesis and Fluorescence Properties Upon Interaction with DNA, J. Fluoresc. 2015, 25, 1637-1643
Jiao X., Liu C., Huang K., Zhang S., He S., Zhao L., Zeng X., Molecular design and synthesis of a pH independent and cell permeant fluorescent dye and its applications, Org. Biomol. Chem., 2015, 13, 6647–6653
Zhang X., Liu Q., Zeng X., Sui J., Cai W., Liu A., Effect of Annealing Temperature on the Shape Memory Properties of Cold-Rolled Dual-Phase Ni-Mn-Ga-Gd Alloy, Acta Metallurgica Sinica-English Lett., 2015, 28, 1403-1406
田涛，刘畅，何松, 曾宪顺, 基于荧光素衍生物单分子器件的二进制全减器和全加器, 高等学校化学学报, 2015, 36, 260-266.
Liang L., Zhao L. and Zeng X., A Highly Selective Turn-on Fluorescent Chemodosimeter for Cu2+ through a Cu2+-Promoted Redox Reaction, J. Fluorescence., 2014, 24, 1671–1677
Liu C., Huang S., Lu Y., He S., Zhao L. and Zeng X., Preparation of ?uorescein-based chemosensors and their sensing behaviors toward silver ions, RSC Advance, 2014, 4, 16109-16114.
He S., Liu Q., Li Y., Wei F., Cai S., Lu Y., Zeng X., Novel rhodamine 6G based chemosensor for Cu2+ and Hg2+ in water, Chem. Res. Chin. Univ., 2014, 30, 32-36.
Chang L., Liu C., He S., Lu Y., Zhang S., Zhao L., Zeng X., Novel styryldehydropyridocolinium derivative as turn-on fluorescent probe for DNA based on an intercalative binding mechanism, Sen. Actuators B 2014, 202, 483–488.
Liu Q., Liu C., Chang L., He S., Lu Y., Zhao L., Zeng X., Tunable PET processes by intercalation of cationic styryl dye in DNA and its application as efficient turn-on fluorescent probe for silver ions, RSC Advance, 2014, 4, 14361-14364.
Chang J., Lu Y., He S., Liu C., Zhao L., Zeng X., Efficient Fluorescent Chemosensor for HSO4- Based on a Strategy of Anion-Induced Rotation-Displaced H-Aggregate, Chem. Commun., 2013, 49, 6259-6261.
Cai S., Lu Y., He S., Wei F., Zhao L., Zeng X., A highly sensitive and selective turn-on fluorescent chemosensor for palladium based on a phosphine-rhodamine conjugate, Chem. Commun., 2013, 49, 822-824.
Liu C., Lu Y., He S., Wang Q., Zhao L., Zeng X., The nature of the styrylindolium dye: transformations among monomer, aggregates and water adducts and its photophysical properties, J. Mater. Chem. C. 2013, 1, 4770-4778.
Wang Q., Liu C., Lu Y., He S., Liu C., Zhao L., Zeng X., Novel Water Soluble Styrylquinolinium Boronic Acid as a Ratiometric Reagent for the Rapid Detection of Hypochlorite, Dyes and Pigments, 2013, 99, 733-739.
Li Y., He S., Lu Y., L. Zhao, Zeng X., Novel mercury sensor based on water soluble styrylindolium Dye, Dyes and Pigments, 2013, 96, 424-429.
Over D., Zeng X., Bornholdt C., Marrot J., Reinaud O., Coordination of Lead(II) in the Supramolecular Environment Provided by a “Two-Story” Calix[6]arene-based N6 Ligand. Inorg. Chem., 2013, 52, 14089-14095
Sun J., Lu Y., Wang L., Cheng D., Sun Y., Zeng X., Fluorescence turn-on detection of DNA based on the aggregation-induced emission of conjugated poly(pyridinium salt)s, Polym. Chem., 2013, 4, 4045-4051.
Wei F., Lu Y., He S., Zhao L., Zeng X., Highly Sensitive Fluorescent Chemosensor for Hypochlorite Anion Based on a Novel Irreversible Ring-Opened Strategy, Anal. Methods, 2012, 4, 616-618.
Wei F., Lu Y., He S., Zhao L., Zeng X., Selective and sensitive fluorescence chemosensor for the hypochlorite anion in water, J. Fluoresc. 2012, 22, 1257–1262.
Han F., Lu Y., Zhang Q., Sun J., Zeng X., Li C., Homogeneous and sensitive DNA detection based on polyelectrolyte complexes of cationic conjugated poly(pyridinium salt)s and DNA, J. Mater. Chem., 2012, 22, 4106-4112.
王炜 何松 陆燕 曾宪顺，基于杯[4]芳烃的银离子荧光探针合成与性能，高等学校化学学报，2012，33，2470-2475
Lu Y., Huang S., Liu Y., He S., Zhao L. and Zeng X., Highly Selective and Sensitive Fluorescent Turn-on Chemosensor for Al3+ Based on a Novel Photoinduced Electron Transfer Approach, Org. Lett. 2011, 13, 5274-5277.
Huang S., He S., Lu Y., Wei F., Zeng X. and Zhao L., Highly sensitive and selective fluorescent chemosensor for Ag+ based on a coumarin-Se2N chelating conjugate, Chem. Commun. 2011, 47, 2408-2410.
Zeng X., Bornholdt C., Over D., Reinaud O., Synthesis of “Two-Story” Calix[6]aza-Cryptands, Org. Lett. 2011, 13, 5660-5663.
Li Y., He S., Lu Y., Zeng X., Novel Hemicyanine Dye as Colorimetric and Fluorometric Dual-modal Chemosensor for Mercury in Water, Org. Biomol. Chem. 2011, 9, 2606-2609.
何松，陆阳，李园园，陆燕，曾宪顺，基于C3v对称性的杯[6]芳烃对Hg2+的荧光选择性识别行为，高等学校化学学报, 2011, 32, 2139-2144.
李园园, 陆燕, 何松, 曾宪顺，基于半青蓝素修饰的汞离子探针比色传感行为研究，高等学校化学学报, 2011, 32, 2123-2127.
Ren Y., Li C., Lu Y., Wang X., Zeng X. Aggregates of cholic acid and benzylamine as templates for the formation of hollow silica spheres, J. Mater. Sci. 2010, 45, 6830–6833.
Zeng X., Wang C., Batsanov A. S., Bryce M. R., Gigon J., Urasinska-Wojcik B., Ashwel G. J., Synthesis and Properties of Functionalized Oligo(arylene) Molecular Wires with Thiolated Termini: Competing Thiol-Au and Nitro-Au Assembly, J. Org. Chem. 2010, 75, 139-136.