writer：张黎明等 // Zhang, L. M.; et al
keywords：天然大分子，生物大分子, 功能材料, 杂化材料 // Natural macromolecules, Biomacromolecules, Functional materials, Hybrid materials
source：期刊
Issue time：2026年
*Corresponding author(s)/通讯作者. #These authors contributed equally to this work/共同第一作者.
[386] Yang, H. K.; Zhang, L. M. * Preparation, self-assembly, loading drug, blood clotting and hemolysis of amphiphilic diblock copolymers based on α-alkyne poly(ε-benzyloxycarbonyl-L-lysine) and α-azido heparin. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 2026, incomplete submission.
[385] Deng, J. J.#; Chen, S. S.#.; Li, N.#; Zhou, J. Y.; Lao, G. J.; Ren, M.; Yang, C.; Yan, L.*; Zhang, L. M.*Amphiphilic beta-cyclodextrin-centered heteroarm star polymers toward the co-delivery of methotrexate and plasmid DNA. Journal of Biomaterials Science, Polymer Edition, 2026, incomplete submission.
[384] Zhang, J. Z. #; Liang, H. S. #; Mao, X. H.; Wang, F.*; Huang, L. L.*; Zhang, L. M.* Gene delivery therapy and photothermal therapy of osteosarcoma via multifunctional spermine-modified amylose@IR-780 nanocomplexes. Journal of Colloid and Interface Science, 2026, incomplete submission.
[383] Wang, H. Z.; Lu, B.; Zhou, J. Y.; Bao, Y. Y.; Guo, S.-Z.*; Zhang, L. M.* Nano-Orchestrated Wet-Adhesive Lentinan/Soy Protein Hydrogels for Photothermally Gated H2S Therapy in Diabetic Wound Repair. Advanced Functional Materials, 2026, Manuscript Status_Submitted.
[382] Ou, J. Q.#; Luo, Y. W.#; Fang, Y.; Xiao, Y.; Zhang, J. C.; Fu, C. P.*; Zhang, L. M*. Injectable Thermosensitive F127/Chitosan Hydrogel with Sustained EGF Release for Diabetic Wound Healing. Biomaterials Science, 2026, Manuscript Status_Submitted.
[381] Zheng, X.; Zhou, J. Y.; Wang, H. Z.; Lu, B.; Lai, J. Y.; Guo, S.-Z.*; Zhang, L. M.* Dual-Modality Cancer Therapy via Light-Triggered CO Release and Photothermal Effects from Engineered Prussian Blue Nanoparticles. Journal of Colloid and Interface Science, 2026, Manuscript Status_Submitted.
[380] Wang, H. Z.; Lu, B.; Zhou, J. Y.; Xia, H. J.; Guo, S.-Z.*; Zhang, L. M.* Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing. Biomacromolecules, 2026, 27, Articles ASAP. (SCI) https://pubs.acs.org/doi/10.1021/acs.biomac.6c00725
[379] Lu, B.; Wang, H. Z.; Zhou, J. Y.; Lai, J. Y.; Zheng, X.; Guo, S.-Z.*; Zhang, L. M.* Intelligent ROS-triggered NO and isotretinoin co-delivery hydrogel 生物dressings for microenvironment modulation and rapid repair of diabetic wounds. Chemical Engineering Journal, 2026, 536, 176060 / 1-13. (SCI) https://doi.org/10.1016/j.cej.2026.176060
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[学术会议/Scientific Conferences-162] 郭双壮*，王含章，陆滨，张黎明. 基于微环境响应的智能生物基水凝胶构建及其糖尿病创面修复研究 (编号_ID-7240, 口头报告). 中国材料大会2026学术年会暨第27届中国国际新材料博览会 (武汉国际博览中心), 2026年7月12日-15日。https://cmc2026.scimeeting.cn
[学术会议/Scientific Conferences-161] 陆滨，王含章，郭双壮，张黎明*. 新型智能水凝胶用于糖尿病伤口 (编号_ID-4070, 墙报). 中国材料大会2026学术年会暨第27届中国国际新材料博览会 (武汉国际博览中心), 2026年7月12日-15日。https://cmc2026.scimeeting.cn
[学术会议/Scientific Conferences-160] 陆滨，王含章，郭双壮，张黎明*. 新型智能水凝胶用于糖尿病伤口 (编号_D4-48, 墙报). 中国化学会第35届学术年会 (重庆科学会堂), 2026年4月11日-14日。 https://www.chemsoc.org.cn/meeting/35th/
摘要：糖尿病慢性创面因长期炎症反应、细菌感染以及组织再生能力受损而难以愈合，仍是亟待解决的临床问题。本研究构建了一种活性氧响应型一氧化氮释放水凝胶体系，以三羟甲基氨基甲烷改性的透明质酸为基体，引入具有天然抗菌活性的 ε-聚赖氨酸，并结合功能化中空介孔杂化二氧化硅纳米颗粒，实现药物负载与刺激响应释放。该水凝胶可在温和条件下快速凝胶化，形成稳定三维网络结构，表现出良好的组织黏附性能、抗菌活性及促愈合潜能。通过结构与功能模块的理性设计，材料在氧化应激条件下可实现异维A酸的可控释放，并进一步触发按需 NO 生成。体内外实验表明，异维A酸与 NO 的释放均呈 ROS 水平依赖性且具可调控特征，从而显著促进创面闭合，增强胶原沉积与血管新生，并改善局部炎症微环境。该水凝胶体系具有良好的生物相容性与智能响应特性，提示其作为多功能创面敷料在糖尿病慢性创面治疗中具有潜在应用价值。